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MDC1 and PIAS1
Number of citations of the paper that reports this interaction (PubMedID
22661230
)
47
Data Source:
BioGRID
(enzymatic study)
MDC1
PIAS1
Description
mediator of DNA damage checkpoint 1
protein inhibitor of activated STAT 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Focal Adhesion
Nuclear Body
Site Of Double-strand Break
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytoskeleton
PML Body
Nuclear Speck
Nuclear Periphery
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
Protein Binding
Chromatin-protein Adaptor Activity
Histone Reader Activity
Transcription Cis-regulatory Region Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
SUMO Ligase Activity
DNA-binding Transcription Factor Binding
Biological Process
DNA Replication Checkpoint Signaling
DNA Repair
Chromatin Organization
DNA Damage Response
Mitotic Intra-S DNA Damage Checkpoint Signaling
Protein K6-linked Ubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Spermatogenesis
Visual Learning
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Sumoylation
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Macromolecule Metabolic Process
Protein-DNA Complex Assembly
Positive Regulation Of Protein Localization To Cell Periphery
Pathways
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
TP53 Regulates Transcription of DNA Repair Genes
G2/M DNA damage checkpoint
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Eosinophil count (
31272903
)
Diastolic blood pressure (
30224653
)
Diverticular disease (
30177863
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Haemorrhoidal disease (
33888516
)
Major depressive disorder (
23377640
)
Number of twin births (
30760885
)
Interacting Genes
42 interacting genes:
ANAPC1
ATM
BARD1
BDKRB1
BRCA1
CASP3
CENPC
CHEK2
COPS5
CREBBP
CSNK2A1
DTX2
EP300
GATA4
H2AX
HDAC10
HDAC8
HINFP
NBN
NCL
NSD2
PIAS1
PIAS4
PRIM1
PTEN
RAD50
RAD51
RNF8
SMC1A
SRPK2
SUMO2
TNKS2
TP53
TP53BP1
UIMC1
USP13
USP15
USP28
USP7
VAMP5
WRN
ZNF251
118 interacting genes:
AKT1
AR
ATXN1
AXIN1
BARD1
BRCA1
CASP8
CBS
CDK4
CEBPA
CEBPE
CHD3
CHUK
CNOT7
CREB1
CREBBP
CSNK2A1
CSRP2
DCLRE1A
DDX21
DDX5
DNM1
DNMT3A
ELK3
EP300
ERG
ESR1
ESR2
FANCI
FHL3
FLI1
GATA4
GLUL
GRM8
GSK3B
GTF2IRD1
H2AZ1
H2BC3
H3C1
HECTD2
HIC1
HTT
IKZF5
JUN
L3MBTL2
LSM3
MAML1
MBD1
MDC1
MDM2
MITF
MORC3
MSX1
MX1
MYB
NCOR1
NFATC1
NIN
NR2F2
NR3C2
NR5A1
NRIP1
PAXIP1
PGR
PIAS2
PIAS4
PLAG1
PML
PPP1CA
PPP1CC
PRDM1
PRPF40A
PTK2
PTPN1
QKI
RAD51
RAD54L2
RBBP6
RELA
RHOB
RPA2
SATB1
SATB2
SERBP1
SETX
SGTA
SKIL
SMAD1
SMAD4
SMAD7
SNAI2
SNIP1
SP3
SPOP
SREBF2
STAT1
SUFU
SUMO1
SUMO1P1
SUMO2
SUMO3
TBP
TERF2
TERF2IP
TEX11
TP53
TP73
TRIM27
TRIM5
TRIM55
TRIM63
TSG101
UBE2I
UBE2L3
YWHAZ
ZBED1
ZNF451
ZNF76
Entrez ID
9656
8554
HPRD ID
16252
16029
Ensembl ID
ENSG00000137337
ENSG00000033800
Uniprot IDs
A0A1U9XBC1
A0A1U9XBE3
A0A1U9XBF2
A1Z5I9
Q14676
O75925
PDB IDs
2ADO
2AZM
2ETX
3K05
3UEO
3UMZ
3UN0
3UNM
3UNN
3UOT
9IF9
1V66
Enriched GO Terms of Interacting Partners
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DNA Repair
DNA Damage Response
DNA Metabolic Process
Double-strand Break Repair
Regulation Of Cellular Response To Stress
Nucleoplasm
Regulation Of DNA Metabolic Process
Regulation Of DNA Repair
Response To Ionizing Radiation
Response To Radiation
Negative Regulation Of Cell Cycle Phase Transition
Cellular Response To Stress
DNA Damage Checkpoint Signaling
Post-translational Protein Modification
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Positive Regulation Of DNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromosome
DNA Recombination
Nucleic Acid Metabolic Process
Regulation Of DNA Recombination
Nucleus
Regulation Of Double-strand Break Repair
Regulation Of Cell Cycle Phase Transition
Chromatin Remodeling
PML Body
Macromolecule Metabolic Process
Protein Modification Process
Chromatin Organization
Cellular Response To Radiation
Regulation Of Double-strand Break Repair Via Homologous Recombination
DNA Strand Resection Involved In Replication Fork Processing
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of DNA Repair
Recombinational Repair
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Site Of Double-strand Break
Regulation Of Primary Metabolic Process
Homologous Recombination
Ubiquitin-modified Histone Reader Activity
Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle Process
Cellular Response To Ionizing Radiation
Positive Regulation Of DNA Recombination
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
DNA Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Chromatin
PML Body
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
Sequence-specific DNA Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Enzyme Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Sumoylation
Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Response To Stress
Cellular Response To Stress
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Cellular Response To Stress
Nucleic Acid Metabolic Process
Chromatin Binding
Intracellular Signal Transduction
SUMO Transferase Activity
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