COPS5 and MAP2K2

Number of citations of the paper that reports this interaction (PubMedID 18624398)
0

Data Source:
BioGRID (two hybrid)

		COPS5	MAP2K2
Description		COP9 signalosome subunit 5	mitogen-activated protein kinase kinase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Peroxisomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Cell-cell Junction Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Translation Initiation Factor Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity DeNEDDylase Activity Enzyme Binding Macrophage Migration Inhibitory Factor Binding Metal Ion Binding Metal-dependent Deubiquitinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity PDZ Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Deneddylation Translation Translational Initiation Proteolysis Negative Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Regulation Of IRE1-mediated Unfolded Protein Response Exosomal Secretion Regulation Of Protein Neddylation	MAPK Cascade Heart Development Positive Regulation Of Gene Expression Schwann Cell Development Thyroid Gland Development Regulation Of Stress-activated MAPK Cascade Peptidyl-serine Autophosphorylation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of DNA-templated Transcription Insulin-like Growth Factor Receptor Signaling Pathway Thymus Development Regulation Of Axon Regeneration Positive Regulation Of Axonogenesis Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Positive Regulation Of Cell Motility Regulation Of Early Endosome To Late Endosome Transport
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)	MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants
Drugs			Bosutinib Trametinib Selumetinib Binimetinib Fostamatinib Pimasertib
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS			Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Height ( 29782485) Lymphocyte count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		113 interacting genes: APCS APP ARFGAP1 ATM ATRN BCL2L14 BCL3 BRD4 BRSK2 BRWD1 BTG3 CACNA1C CD274 CD93 CDKN1B CEBPA CENPT CFAP298 COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4B CUL5 DDB1 DDO DSCAM ERN1 ERRFI1 ESR1 F2RL1 GATD3 GFER GFI1B GPS1 GRIK1 GTPBP3 HAND2 HIF1A HNF4A HNF4G HTR6 HUNK IKBKB ITGB2 JUN JUND LASP1 LCOR MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF MORC3 MSRA MTRES1 MYG1 NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 OPRM1 PEA15 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 PUM1 PUM2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SIAH1 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 STAMBPL1 SUMO3 TOP2A TP53 TTC3 TXN TYK2 UCHL1 VTN WDR4 WNK1 YWHAG	20 interacting genes: ARAF BRAF CASP9 CCNDBP1 CNKSR1 COPS5 DUSP3 GRIN1 GRIN2D HNRNPK LAMTOR3 LIG4 MAPK1 MAPK3 MAPK8 MOS RAF1 RGS12 RIPOR2 ZNF207
Entrez ID		10987	5605
HPRD ID		06888	03164
Ensembl ID		ENSG00000121022	ENSG00000126934
Uniprot IDs		A0A024R7W9 Q92905	B3KS97 P36507
PDB IDs		4D10 4D18 4F7O 4WSN 5JOG 5JOH 5M5Q 6R6H 6R7F 6R7H 6R7I 8H38 8H3A 8H3F	1S9I 4H3Q
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Cell Communication Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Primary Metabolic Process Cellular Response To Stress Positive Regulation Of Signal Transduction Nucleoplasm Positive Regulation Of Metabolic Process Protein Deneddylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Protein Neddylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Transcription Coactivator Binding Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription MAPK Cascade Protein Modification Process Response To Stress Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Programmed Cell Death Cell Death Transcription Regulator Complex Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process DNA-binding Transcription Factor Activity Cellular Response To Oxygen-containing Compound Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Protein-containing Complex	MAPK Cascade MAP Kinase Kinase Kinase Activity Face Development Thyroid Gland Development Intracellular Signal Transduction Protein Serine Kinase Activity ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Thymus Development Regulation Of Signal Transduction Regulation Of MAPK Cascade MAP Kinase Activity Pseudopodium Protein Kinase Activity Schwann Cell Development ERBB Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Peptidyl-serine Phosphorylation Stress-activated MAPK Cascade ERBB2 Signaling Pathway Regulation Of Intracellular Signal Transduction Stress-activated Protein Kinase Signaling Cascade Signal Transduction Kinase Activity Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Regulation Of Peptidyl-serine Phosphorylation Cytoplasm Regulation Of Chromosome Organization Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Granulocyte Chemotaxis Response To Epidermal Growth Factor Negative Regulation Of Apoptotic Process ERK1 And ERK2 Cascade Long-term Synaptic Potentiation Protein Phosphorylation Negative Regulation Of Programmed Cell Death NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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