MDC1 and ZNF251

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		MDC1	ZNF251
Description		mediator of DNA damage checkpoint 1	zinc finger protein 251
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body Site Of Double-strand Break	Nucleus
	Molecular Function	Protein Binding Chromatin-protein Adaptor Activity Histone Reader Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication Checkpoint Signaling DNA Repair Chromatin Organization DNA Damage Response Mitotic Intra-S DNA Damage Checkpoint Signaling Protein K6-linked Ubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Homeostasis
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Eosinophil count ( 31272903)	Alanine aminotransferase levels ( 33547301) Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		42 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 USP7 VAMP5 WRN ZNF251	14 interacting genes: FEZ1 FEZ2 FHL5 KRTAP10-9 MDC1 MX1 PAXIP1 RBM11 RSPH1 SMAD1 SPTBN1 TNFAIP3 TRIM41 TSC22D2
Entrez ID		9656	90987
HPRD ID		16252	19696
Ensembl ID		ENSG00000137337	ENSG00000198169
Uniprot IDs		A0A1U9XBC1 A0A1U9XBE3 A0A1U9XBF2 A1Z5I9 Q14676	Q9BRH9
PDB IDs		2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT 9IF9
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of DNA Repair Response To Ionizing Radiation Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Stress DNA Damage Checkpoint Signaling Post-translational Protein Modification Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Positive Regulation Of DNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Nucleic Acid Metabolic Process Regulation Of DNA Recombination Nucleus Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Phase Transition Chromatin Remodeling PML Body Macromolecule Metabolic Process Protein Modification Process Chromatin Organization Cellular Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Macromolecule Metabolic Process Response To Stress Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Positive Regulation Of DNA Repair Recombinational Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Site Of Double-strand Break Regulation Of Primary Metabolic Process Homologous Recombination Ubiquitin-modified Histone Reader Activity Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Cellular Response To Ionizing Radiation Positive Regulation Of DNA Recombination	Negative Regulation Of Autophagosome Assembly Response To Muramyl Dipeptide
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