SCAMP1 and SPG21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SCAMP1	SPG21
Description		secretory carrier membrane protein 1	SPG21 abhydrolase domain containing, maspardin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Trans-Golgi Network Membrane Specific Granule Membrane Zymogen Granule Membrane Synapse Recycling Endosome Membrane	Cytoplasm Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding CD4 Receptor Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Endocytosis Protein Transport Establishment Of Localization In Cell	Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Locomotory Behavior Gene Expression Neuron Maturation Collateral Sprouting Antigen Receptor-mediated Signaling Pathway Neuromuscular Process Limb Development Response To Epidermal Growth Factor
Pathways		Neutrophil degranulation
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Hippocampal atrophy ( 19668339) Intraocular pressure ( 29785010) Platelet count ( 32888494) Plateletcrit ( 32888494) Triglycerides ( 26780889)
Interacting Genes		27 interacting genes: ARFIP1 ARFIP2 CFTR EGFR EPS15 GAD2 ITSN1 KRTAP13-1 MTERF3 NDRG4 PBX3 PCYT1A PTPN9 SCAMP2 SLC9A7 SNAP23 SNAP25 SNCA SPG21 SYNRG TASOR2 TBRG4 THAP4 TP53 TTPA UBE3A ZMIZ2	161 interacting genes: - ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARMC12 ARMC7 ATP5ME BORCS6 BSND CCDC102B CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CT55 CTIF CTPS2 CUTC DCTPP1 DRC12 DRC4 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPMIP5 SPMIP6 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629
Entrez ID		9522	51324
HPRD ID		06072	10492
Ensembl ID		ENSG00000085365	ENSG00000090487
Uniprot IDs		A0A087WXB0 B4E2V7 O15126	Q9NZD8
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Priming Regulation Of Golgi Lumen Acidification Cytosol Vesicle-mediated Transport In Synapse Exocytosis Import Into Cell Regulation Of Protein Localization Establishment Of Localization In Cell Postsynaptic Endocytic Zone Vesicle Docking Establishment Of Protein Localization Embryonic Organ Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Endosome Positive Regulation Of Receptor Recycling Organelle Localization By Membrane Tethering Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Locomotory Behavior Synaptic Vesicle Membrane Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular PH Membrane Docking Regulation Of Intracellular PH Vesicle-mediated Transport Secretion By Cell Intracellular Vesicle Regulation Of PH Recycling Endosome Membrane Post-Golgi Vesicle-mediated Transport Positive Regulation Of Protein Localization Endocytosis Regulation Of Receptor Recycling Embryonic Placenta Development Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Trans-Golgi Network Membrane Regulation Of Arp2/3 Complex-mediated Actin Nucleation Golgi Apparatus Neurotransmitter Uptake Phospholipid Binding Phosphatidylinositol-4-phosphate Binding 14-3-3 Protein Binding Regulation Of Cellular Localization Recycling Endosome Positive Regulation Of Signaling Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multivesicular Body, Internal Vesicle Lumen	Protein Binding Identical Protein Binding Motile Cilium Structural Molecule Activity Guanine Salvage Purine Nucleobase Biosynthetic Process Hypoxanthine Phosphoribosyltransferase Activity Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Sperm Flagellum Cilium Movement Involved In Cell Motility Hypoxanthine Biosynthetic Process Protein-containing Complex Organization
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