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AURKB and HIST2H3C
Number of citations of the paper that reports this interaction (PMID
20929775
)
64
Data Source:
BioGRID
(pull down)
AURKB
HIST2H3C
Gene Name
aurora kinase B
histone cluster 2, H3c
Image
Gene Ontology Annotations
Cellular Component
Condensed Chromosome, Centromeric Region
Condensed Nuclear Chromosome, Centromeric Region
Nucleus
Spindle
Cytosol
Spindle Microtubule
Chromocenter
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Spindle Midzone
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Extracellular Vesicular Exosome
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
Negative Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
Aging
Cell Proliferation
Attachment Of Spindle Microtubules To Kinetochore
Abscission
Histone Modification
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Spindle Checkpoint
Negative Regulation Of Protein Binding
Negative Regulation Of Cytokinesis
Positive Regulation Of Cytokinesis
Protein Localization To Kinetochore
Cellular Response To UV
Cleavage Furrow Formation
Spindle Stabilization
Histone H3-S28 Phosphorylation
Protein Autophosphorylation
Mitotic Spindle Midzone Assembly
Regulation Of Chromosome Segregation
Chromatin Silencing At RDNA
Blood Coagulation
Gene Expression
DNA Methylation On Cytosine
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Gene Expression, Epigenetic
Pathways
Mitotic Prometaphase
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of mitotic cell cycle
Mitotic Anaphase
Mitotic Metaphase and Anaphase
APC/C-mediated degradation of cell cycle proteins
Cell Cycle, Mitotic
M Phase
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-Protein Interactions
48 interactors:
AJUBA
ANKZF1
APP
BCL2L11
BIRC5
CBX3
CDCA8
CENPA
CIB1
CYLD
DCUN1D1
DES
EVI5
FBXL2
FLOT1
GFAP
GNB2L1
GSG2
HIST1H3A
HIST2H3C
HIST3H3
INCENP
KIF20A
KLHL13
KLHL21
KLHL9
LATS1
LATS2
MAPRE1
MAPRE2
MAPRE3
NCAPH
NDC80
NSUN2
NUF2
PPP2R4
PSMA3
RACGAP1
RASA1
RASSF1
SEPT1
SKA1
SKA3
SUMO1
SUMO2
TACC1
TBL3
TGFBR1
61 interactors:
ARID4A
ATRX
AURKB
BIRC5
BRD1
BRD4
BRD7
BRPF1
CDCA8
CDK8
CHUK
COPRS
DDB2
DNMT3L
EHMT2
ELP3
EP300
HDGFRP2
INCENP
ING1
JADE1
KAT2A
KAT2B
KAT5
KAT6A
KDM1A
KDM2A
KDM3A
KDM4C
KDM6A
KMT2A
KMT2B
KMT2C
KMT2D
MSL2
MUM1
NAP1L4
NASP
NCOA6
NRD1
PHF21A
PIM1
PKN1
PRMT6
PTMA
RBBP4
RBBP5
RERE
RNF20
RNF4
RPS6KA5
SETD1A
SETD1B
SETD7
SMARCA4
SMYD2
STAT6
TBL1X
UHRF1
VRK1
WHSC1
Entrez ID
9212
126961
HPRD ID
05397
11822
Ensembl ID
ENSG00000178999
Uniprot IDs
Q96GD4
Q71DI3
PDB IDs
4AF3
2IIJ
2X4W
2X4X
2X4Y
3AV1
3DB3
3MO8
3QO2
3R93
Enriched GO Terms of Interacting Partners
?
Cell Cycle
Cell Division
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cell Cycle Process
Mitotic Nuclear Division
Organelle Organization
Chromosome Segregation
Cytokinesis
Regulation Of Cell Cycle
Regulation Of Microtubule-based Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Microtubule Cytoskeleton Organization
Sister Chromatid Segregation
Mitotic Spindle Organization
Microtubule Cytoskeleton Organization
Regulation Of Cellular Component Organization
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Complex Assembly
Positive Regulation Of Microtubule Plus-end Binding
Regulation Of Cytoskeleton Organization
Cellular Localization
Protein Complex Localization
Regulation Of Organelle Organization
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Microtubule Polymerization Or Depolymerization
Microtubule-based Process
Cellular Process
Mitotic Sister Chromatid Segregation
Positive Regulation Of Cell Cycle
Regulation Of Protein Localization
Protein Modification By Small Protein Conjugation
Positive Regulation Of Proteolysis
Positive Regulation Of Catalytic Activity
Regulation Of Catalytic Activity
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Cell Cycle Process
Cytoskeleton Organization
Positive Regulation Of Protein Modification Process
Regulation Of Protein Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cytokinesis
Negative Regulation Of Catalytic Activity
Spindle Organization
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Chromatin Organization
Histone Modification
Chromosome Organization
Peptidyl-lysine Modification
Organelle Organization
Peptidyl-amino Acid Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Cellular Protein Modification Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Histone Methylation
Gene Expression
Peptidyl-lysine Methylation
Methylation
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Protein Methylation
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Histone Lysine Methylation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Protein Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Histone Acetylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
Internal Protein Amino Acid Acetylation
Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Acetylation
Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Protein Metabolic Process
Histone H3 Acetylation
Positive Regulation Of Cellular Biosynthetic Process
Histone H3-K4 Methylation
Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Tagcloud
?
allele
birc5
cdca8
consortium
contribution
cpc
division
european
exon
familial
fifteen
fixed
genotyped
incenp
inherited
investigates
meta
modest
passenger
pivotal
rs1675126
rs2071214
snp
snps
spite
sporadic
synonymous
top
variability
Tagcloud (Difference)
?
allele
birc5
cdca8
consortium
contribution
cpc
division
european
exon
familial
fifteen
fixed
genotyped
incenp
inherited
investigates
meta
modest
passenger
pivotal
rs1675126
rs2071214
snp
snps
spite
sporadic
synonymous
top
variability
Tagcloud (Intersection)
?