AURKB and EVI5

Number of citations of the paper that reports this interaction (PMID 16764853)
5

Data Source:
BioGRID (affinity chromatography technology, pull down)

		AURKB	EVI5
Gene Name		aurora kinase B	ecotropic viral integration site 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Nucleus Golgi Apparatus Microtubule Organizing Center Spindle Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	Rab GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation	Cell Cycle Multicellular Organismal Development Cell Proliferation Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Cell Division Regulation Of Cilium Assembly
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Multiple sclerosis ( 19525955 21833088)
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	4 interactors: AURKB BIRC5 FBXO5 INCENP
Entrez ID		9212	7813
HPRD ID		05397	04249
Ensembl ID		ENSG00000178999	ENSG00000067208
Uniprot IDs		Q96GD4	F5H4R0 O60447 Q59FE7
PDB IDs		4AF3
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	Mitotic Nuclear Division Cell Division Spindle Assembly Cytokinesis Spindle Organization Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Mitotic Spindle Assembly Regulation Of Cell Division Cell Cycle Spindle Checkpoint Mitotic Spindle Organization Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Microtubule-based Process Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Division Inhibition Of APC-Cdc20 Complex Activity Regulation Of Organelle Organization Regulation Of Cell Cycle Protein Complex Assembly Regulation Of Type B Pancreatic Cell Proliferation Organelle Organization Cytoskeleton Organization Histone H3-S28 Phosphorylation Positive Regulation Of Cell Cycle Process Cell Cycle Checkpoint Positive Regulation Of Exit From Mitosis Spindle Stabilization Negative Regulation Of APC-Cdc20 Complex Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Abscission Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Spindle Assembly Involved In Female Meiosis I Mitotic Spindle Elongation Spindle Assembly Involved In Meiosis Cellular Protein Complex Assembly Negative Regulation Of Proteolysis Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular
Tagcloud (Difference) ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	abscission anaphase biacore bub2 cdc16 colocalizes compete cooperate coordinate cyclosome cytokinesis displays emi1 endosome endosomes fip3 gtpase gtpases mislocalization partitioning perturbs rab rab11 rab11a rab11b recycling redistributing tre vesicular
Tagcloud (Intersection) ?