AURKB and ANKZF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		AURKB	ANKZF1
Gene Name		aurora kinase B	ankyrin repeat and zinc finger domain containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	7 interactors: APP AURKB CA2 CTTN DNAJB11 NRSN2 STAT6
Entrez ID		9212	55139
HPRD ID		05397	07673
Ensembl ID		ENSG00000178999	ENSG00000163516
Uniprot IDs		Q96GD4	Q9H8Y5
PDB IDs		4AF3
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	T-helper 1 Cell Lineage Commitment Synaptic Growth At Neuromuscular Junction Positive Regulation Of Dipeptide Transmembrane Transport Regulation Of Protein Binding Histone H3-S28 Phosphorylation Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular PH Reduction Interleukin-4-mediated Signaling Pathway Spindle Stabilization Regulation Of Chloride Transport Positive Regulation Of Isotype Switching To IgE Isotypes Collateral Sprouting Axon Midline Choice Point Recognition Abscission Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Cycle Process Axon Choice Point Recognition Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation T-helper Cell Lineage Commitment Angiotensin-activated Signaling Pathway Dendritic Spine Maintenance Regulation Of Binding T-helper 1 Cell Differentiation Negative Regulation Of Cytokinesis CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Neuron Remodeling Protein Localization To Kinetochore Positive Regulation Of Cell Cycle Anatomical Structure Morphogenesis Response To Abiotic Stimulus Substrate-dependent Cell Migration, Cell Extension Spindle Midzone Assembly Regulation Of Developmental Growth Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Chromosome, Centromeric Region Negative Regulation Of Type 2 Immune Response Cell Adhesion Response To Light Stimulus Cellular Protein Complex Assembly Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Synaptic Transmission, GABAergic Multicellular Organismal Development Positive Regulation Of Bone Resorption Cellular Response To Reactive Nitrogen Species Histone-serine Phosphorylation Cellular Response To Fluid Shear Stress Positive Regulation Of Isotype Switching
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?