AURKB and LRRK2

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		AURKB	LRRK2
Description		aurora kinase B	leucine rich repeat kinase 2
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone	Golgi Membrane Extracellular Space Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Golgi-associated Vesicle Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Microvillus Synaptic Vesicle Membrane Axon Dendrite Growth Cone Synaptic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane Mitochondrial Membrane Cytoplasmic Side Of Mitochondrial Outer Membrane Dendrite Cytoplasm Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Terminal Bouton Perikaryon Amphisome Autolysosome Membrane Raft Synapse Phagocytic Vesicle Intracellular Organelle Lumen Extracellular Exosome Endoplasmic Reticulum Exit Site Multivesicular Body, Internal Vesicle Postsynapse Glutamatergic Synapse Caveola Neck Presynaptic Cytosol Ribonucleoprotein Complex Wnt Signalosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity	SNARE Binding Nucleotide Binding Magnesium Ion Binding Actin Binding GTPase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity GTPase Activator Activity Protein Binding ATP Binding GTP Binding Microtubule Binding Tubulin Binding Kinase Activity Transferase Activity Hydrolase Activity Syntaxin-1 Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Small GTPase Binding GTP-dependent Protein Kinase Activity Peroxidase Inhibitor Activity Co-receptor Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Kinase A Binding Protein Serine Kinase Activity Beta-catenin Destruction Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation	MAPK Cascade Protein Phosphorylation Protein Import Into Nucleus Endocytosis Autophagy Response To Oxidative Stress Mitochondrion Organization Endoplasmic Reticulum Organization Golgi Organization Lysosome Organization Cell Surface Receptor Signaling Pathway JNK Cascade Rho Protein Signal Transduction Spermatogenesis Neuromuscular Junction Development Intracellular Protein Localization Determination Of Adult Lifespan Cellular Response To Starvation Anatomical Structure Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Protein Processing Negative Regulation Of Neuron Projection Development Regulation Of Neuron Maturation Vesicle-mediated Transport Negative Regulation Of Macroautophagy Calcium-mediated Signaling Striatum Development Olfactory Bulb Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Cell Differentiation Regulation Of Proteolysis Neuron Differentiation Regulation Of Cell Projection Organization Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of GTPase Activity Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Regulation Of SNARE Complex Assembly Intracellular Signal Transduction Regulation Of Kidney Size Exploration Behavior Locomotory Exploration Behavior Regulation Of Lysosomal Lumen PH Regulation Of Locomotion Regulation Of Membrane Potential Positive Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Negative Regulation Of Notch Signaling Pathway GTP Metabolic Process Protein Autophosphorylation Intracellular Distribution Of Mitochondria Animal Organ Development Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Mitochondrion Localization Regulation Of Mitochondrial Depolarization Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Excitatory Postsynaptic Potential Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Morphogenesis Protein Localization To Mitochondrion Protein Localization To Endoplasmic Reticulum Exit Site Cellular Response To Manganese Ion Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Excitatory Postsynaptic Potential Neuron Projection Arborization Regulation Of CAMP/PKA Signal Transduction Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Autoubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Neuroblast Proliferation Regulation Of Synaptic Vesicle Transport Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Autophagosome Assembly Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Cellular Response To Dopamine Positive Regulation Of Microglial Cell Activation Cellular Response To Curcumin Wnt Signalosome Assembly Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Exocytosis Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation	PTK6 promotes HIF1A stabilization
Drugs		Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901	Fostamatinib
Diseases			Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)	Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 28067908) Daytime sleep phenotypes ( 27126917) Inflammatory bowel disease ( 23128233 28067908) Leprosy ( 25642632) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) Parkinson's disease ( 19915576 31660654 28892059 28011712 27182965 25064009 24842889 22438815 21738487 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37	143 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B APEX2 APP ARFGAP1 ARHGEF7 ARK2N AURKB BAG1 BAG2 BAG3 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2
Entrez ID		9212	120892
HPRD ID		05397	10613
Ensembl ID		ENSG00000178999	ENSG00000188906
Uniprot IDs		Q96GD4	Q17RV3 Q5S007
PDB IDs		4AF3	2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XAF 6XR4 7LHT 7LHW 7LI3 7LI4 7THY 7THZ 8FO2 8FO7 8FO8 8FO9 8SMC 8TXZ 8TYQ 8TZB 8TZC 8TZE 8TZF 8TZG 8TZH 8U1B 8U7H 8U7L 8U8A 8U8B 8VH4 8VH5 9C61 9C76 9CHO
Enriched GO Terms of Interacting Partners?		Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Binding Cytosol Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cellular Response To Stress Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Apoptotic Process MAP Kinase Kinase Activity Signal Transduction Cytoplasm Programmed Cell Death Frizzled Binding Cell Death Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Macromolecule Metabolic Process Positive Regulation Of Neuron Projection Arborization Nucleotide Binding ATP Binding Protein Phosphorylation Regulation Of JNK Cascade Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Cellular Response To Stress Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Projection Organization Stress-activated Protein Kinase Signaling Cascade Regulation Of Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Developmental Cell Growth JUN Kinase Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Neuron Projection Extension Cellular Response To Topologically Incorrect Protein Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Import Into Nucleus Response To Light Stimulus Regulation Of Protein Modification Process Regulation Of Proteolysis Phosphorylation Response To Radiation Protein Metabolic Process
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