AURKB and INCENP

Number of citations of the paper that reports this interaction (PMID 12925766)
133

Data Source:
HPRD (in vitro)

		AURKB	INCENP
Gene Name		aurora kinase B	inner centromere protein antigens 135/155kDa
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Lateral Element Central Element Pericentric Heterochromatin Spindle Cytosol Microtubule Chromocenter Midbody Protein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation	Mitotic Cell Cycle Cytokinesis Chromosome Segregation Mitotic Nuclear Division
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	10 interactors: AURKA AURKB AURKC BIRC5 CBX5 CDCA8 EVI5 FLOT1 H2AFZ HIST2H3C
Entrez ID		9212	3619
HPRD ID		05397	05103
Ensembl ID		ENSG00000178999	ENSG00000149503
Uniprot IDs		Q96GD4	Q9NQS7
PDB IDs		4AF3	2QFA 4AF3
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	Mitotic Spindle Organization Cell Division Histone-serine Phosphorylation Spindle Assembly Mitotic Spindle Assembly Mitotic Nuclear Division Positive Regulation Of Cell Division Spindle Organization Histone Phosphorylation Spindle Stabilization Regulation Of Cytokinesis Positive Regulation Of Cell Cycle Process Chromosome Segregation Regulation Of Cell Division Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Positive Regulation Of Cell Cycle Mitotic Cell Cycle Process Cell Cycle Mitotic Cell Cycle Spindle Midzone Assembly Attachment Of Spindle Microtubules To Kinetochore Cellular Localization Cytokinesis Peptidyl-serine Phosphorylation Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Cell Cycle Process Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Positive Regulation Of Mitotic Nuclear Division Spindle Checkpoint Establishment Of Chromosome Localization Negative Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Negative Regulation Of Protein Binding Microtubule Anchoring Regulation Of Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Histone Modification Chromosome Organization Organelle Localization Protein Complex Assembly Protein Localization Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Binding
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		allele aurkb birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability