AURKB and PPP2R4

Number of citations of the paper that reports this interaction (PMID 20593489)
5

Data Source:
BioGRID (enzymatic study)

		AURKB	PPP2R4
Gene Name		aurora kinase B	protein phosphatase 2A activator, regulatory subunit 4
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Receptor Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Type 2A Regulator Activity ATPase Activity Protein Homodimerization Activity Protein Heterodimerization Activity Protein Phosphatase 2A Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation	Protein Peptidyl-prolyl Isomerization Metabolic Process Mitotic Spindle Organization In Nucleus Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	19 interactors: AKT1 AMOT APP AURKB BCL2 CCNG1 CCNG2 CSNK2A1 CYLD EIF4EBP1 H2AFX HDAC4 MAPT MID1 PIM1 PPP2R3A PRKCB RACGAP1 SRC
Entrez ID		9212	5524
HPRD ID		05397	02858
Ensembl ID		ENSG00000178999	ENSG00000119383
Uniprot IDs		Q96GD4	B4DZF8 Q15257
PDB IDs		4AF3	2G62 2HV6 2HV7 2IXM
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	Regulation Of Cell Cycle Cell Cycle Regulation Of Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Cell Death Death Regulation Of Cellular Component Organization Organelle Organization Multicellular Organismal Development Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Regulation Of Signal Transduction Regulation Of Microtubule-based Process Apoptotic Process Developmental Process Regulation Of Signaling Cellular Response To Stimulus Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Cycle Checkpoint Regulation Of Cell Cycle Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Binding Response To Stress Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Nervous System Development Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Cell Growth Negative Regulation Of Mitochondrial Depolarization Regulation Of Growth Negative Regulation Of Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Protein Modification Process
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
Tagcloud (Difference) ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	al355149 algorithm annotation array cisplatin dataset deregulated deregulation existing fam46a fluorouracil lnc lncrna lncrnas man1a2 mbl2 microdissected ncfans nodal noticed paclitaxel reannotation reserve scc sprr2d stxbp5 tongue tumorigenic validate
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