AURKB and GSG2

Number of citations of the paper that reports this interaction (PMID 21658950)
20

Data Source:
BioGRID (enzymatic study)

		AURKB	GSG2
Gene Name		aurora kinase B	germ cell associated 2 (haspin)
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Nucleus Chromosome Cytoplasm Centrosome Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Histone Kinase Activity (H3-T3 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation	Protein Phosphorylation Mitotic Sister Chromatid Cohesion Intracellular Signal Transduction Protein Localization To Chromosome, Centromeric Region Regulation Of Spindle Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H3-T3 Phosphorylation Involved In Chromosome Passenger Complex Localization To Kinetochore
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	2 interactors: AURKB HIST1H3A
Entrez ID		9212	83903
HPRD ID		05397	17083
Ensembl ID		ENSG00000178999	ENSG00000177602
Uniprot IDs		Q96GD4	A0PJ70 Q8TF76
PDB IDs		4AF3	2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	Histone H3-S28 Phosphorylation Spindle Stabilization Abscission Cleavage Furrow Formation Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Protein Localization To Kinetochore Negative Regulation Of Cytokinesis Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Chromatin Organization DNA Methylation On Cytosine Chromatin Silencing At RDNA Histone-serine Phosphorylation Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Regulation Of Gene Silencing Chromosome Organization Protein Complex Assembly Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome Chromatin Silencing Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Histone Phosphorylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Mitotic Spindle Organization Spindle Checkpoint Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cytokinesis Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To UV DNA Methylation Regulation Of Lymphocyte Apoptotic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Gene Expression, Epigenetic Cellular Component Assembly Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	adapted asp atp atypical bonds catalytic dfg equilibrium h3k4 h3t3 haspin his651ala inserts iodotubercidin kinetic lacks loop lys mitosis motifs neighborhood normally phosphorylates recognition segment stabilized tail thr weakly
Tagcloud (Difference) ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	adapted asp atp atypical bonds catalytic dfg equilibrium h3k4 h3t3 haspin his651ala inserts iodotubercidin kinetic lacks loop lys mitosis motifs neighborhood normally phosphorylates recognition segment stabilized tail thr weakly
Tagcloud (Intersection) ?