AURKB and NUF2

Number of citations of the paper that reports this interaction (PubMedID 14602875)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		AURKB	NUF2
Description		aurora kinase B	NUF2 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity	Protein Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation	Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901
Diseases
GWAS		Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)	Asthma ( 29273806) Bipolar disorder ( 34002096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Diffusing capacity of carbon monoxide ( 30694715) Height ( 28552196) Myopia ( 27182965)
Interacting Genes		57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37	11 interacting genes: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 OGT SDCBP2
Entrez ID		9212	83540
HPRD ID		05397	10817
Ensembl ID		ENSG00000178999	ENSG00000143228
Uniprot IDs		Q96GD4	Q9BZD4
PDB IDs		4AF3	2VE7 3IZ0 8G0P
Enriched GO Terms of Interacting Partners?		Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis	Mitotic Spindle Organization Membraneless Organelle Assembly Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Kinetochore Kinetochore Organization Organelle Assembly Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle Midzone Attachment Of Spindle Microtubules To Kinetochore Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis I Chromosome, Centromeric Region Kinetochore Binding Chromosome Passenger Complex Midbody Cell Cycle G2/M Phase Transition Microtubule Cytoskeleton Organization Microtubule-based Process Mitotic Spindle Midzone Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Microtubule Cytoskeleton Spindle Assembly Involved In Female Meiosis Kinetochore Assembly Cytoskeleton Organization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly Regulation Of Sister Chromatid Segregation Condensed Chromosome, Centromeric Region Positive Regulation Of Cell Cycle Checkpoint Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Segregation Meiotic Spindle Organization Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Segregation Regulation Of Nuclear Division Protein Serine/threonine/tyrosine Kinase Activity Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Division Organelle Localization Mitotic Spindle Pole Regulation Of Mitotic Cell Cycle Spindle Microtubule Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Spindle
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