AURKB and NUF2

Number of citations of the paper that reports this interaction (PMID 14602875)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		AURKB	NUF2
Gene Name		aurora kinase B	NUF2, NDC80 kinetochore complex component
Image
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	10 interactors: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 SDCBP2
Entrez ID		9212	83540
HPRD ID		05397	10817
Ensembl ID		ENSG00000178999	ENSG00000143228
Uniprot IDs		Q96GD4	Q9BZD4
PDB IDs		4AF3	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Organization Spindle Stabilization Attachment Of Mitotic Spindle Microtubules To Kinetochore Microtubule Anchoring Mitotic Nuclear Division Mitotic Cell Cycle Microtubule-based Process Cellular Localization Histone-serine Phosphorylation Spindle Organization Organelle Localization Cell Division Microtubule Cytoskeleton Organization Maintenance Of Protein Location In Cell Maintenance Of Protein Location Organelle Assembly Chromosome Organization Kinetochore Assembly Maintenance Of Location In Cell Protein Localization Cytoskeleton Organization Organelle Organization Kinetochore Organization Histone Phosphorylation Negative Regulation Of Microtubule Depolymerization Chromosome Segregation Cell Cycle Mitotic Cell Cycle Process Regulation Of Cell Division Centromere Complex Assembly Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cytokinesis Negative Regulation Of Protein Binding Establishment Of Organelle Localization Cellular Protein Complex Assembly Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Spindle Checkpoint Mitotic Sister Chromatid Segregation Spindle Assembly Protein Complex Assembly Sister Chromatid Segregation Cell Cycle Process Negative Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Negative Regulation Of Binding Spindle Assembly Involved In Female Meiosis I Regulation Of Cell Cycle Process Regulation Of Protein Depolymerization
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	ams2 ams2p bioinformatics cenpa centromere centromeres centromeric cnp1 cnp1p defining disrupted gata identifies incorporation kinetochore linker mal2 microarrays mis12 mis18 nucleosome nucleosomes participating pombe positioned positioning regularly schizosaccharomyces tiling
Tagcloud (Difference) ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability	ams2 ams2p bioinformatics cenpa centromere centromeres centromeric cnp1 cnp1p defining disrupted gata identifies incorporation kinetochore linker mal2 microarrays mis12 mis18 nucleosome nucleosomes participating pombe positioned positioning regularly schizosaccharomyces tiling
Tagcloud (Intersection) ?