AURKB and NSUN2

Number of citations of the paper that reports this interaction (PMID 17215513)
18

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		AURKB	NSUN2
Gene Name		aurora kinase B	NOP2/Sun RNA methyltransferase family, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome, Centromeric Region Condensed Nuclear Chromosome, Centromeric Region Nucleus Spindle Cytosol Spindle Microtubule Chromocenter Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Nucleus Nucleolus Cytoplasm Spindle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding	TRNA Binding TRNA (cytosine-5-)-methyltransferase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of B Cell Apoptotic Process Protein Phosphorylation Aging Cell Proliferation Attachment Of Spindle Microtubules To Kinetochore Abscission Histone Modification Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Spindle Checkpoint Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Spindle Stabilization Histone H3-S28 Phosphorylation Protein Autophosphorylation Mitotic Spindle Midzone Assembly Regulation Of Chromosome Segregation	Mitotic Nuclear Division TRNA Methylation Cell Division
Pathways		Mitotic Prometaphase APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of mitotic cell cycle Mitotic Anaphase Mitotic Metaphase and Anaphase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS			Visceral fat ( 22589738)
Protein-Protein Interactions		48 interactors: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CENPA CIB1 CYLD DCUN1D1 DES EVI5 FBXL2 FLOT1 GFAP GNB2L1 GSG2 HIST1H3A HIST2H3C HIST3H3 INCENP KIF20A KLHL13 KLHL21 KLHL9 LATS1 LATS2 MAPRE1 MAPRE2 MAPRE3 NCAPH NDC80 NSUN2 NUF2 PPP2R4 PSMA3 RACGAP1 RASA1 RASSF1 SEPT1 SKA1 SKA3 SUMO1 SUMO2 TACC1 TBL3 TGFBR1	1 interactors: AURKB
Entrez ID		9212	54888
HPRD ID		05397	08620
Ensembl ID		ENSG00000178999	ENSG00000037474
Uniprot IDs		Q96GD4	Q08J23
PDB IDs		4AF3
Enriched GO Terms of Interacting Partners?		Cell Cycle Cell Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process Mitotic Nuclear Division Organelle Organization Chromosome Segregation Cytokinesis Regulation Of Cell Cycle Regulation Of Microtubule-based Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Sister Chromatid Segregation Mitotic Spindle Organization Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Plus-end Binding Regulation Of Cytoskeleton Organization Cellular Localization Protein Complex Localization Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Microtubule Polymerization Or Depolymerization Microtubule-based Process Cellular Process Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Regulation Of Protein Localization Protein Modification By Small Protein Conjugation Positive Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Negative Regulation Of Wnt Signaling Pathway Regulation Of Cell Cycle Process Cytoskeleton Organization Positive Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of Catalytic Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process	Histone H3-S28 Phosphorylation Spindle Stabilization Abscission Mitotic Spindle Midzone Assembly Cleavage Furrow Formation Mitotic Spindle Elongation Protein Localization To Kinetochore Negative Regulation Of Cytokinesis Spindle Midzone Assembly Protein Localization To Chromosome, Centromeric Region Negative Regulation Of B Cell Apoptotic Process Attachment Of Spindle Microtubules To Kinetochore Histone-serine Phosphorylation Regulation Of B Cell Apoptotic Process Mitotic Spindle Assembly Protein Localization To Chromosome Positive Regulation Of Cytokinesis Negative Regulation Of Microtubule Depolymerization Histone Phosphorylation Mitotic Spindle Organization Spindle Checkpoint Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Cytokinesis Negative Regulation Of Leukocyte Apoptotic Process Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To UV Regulation Of Lymphocyte Apoptotic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Spindle Assembly Cellular Response To Light Stimulus Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Binding Cytokinesis Regulation Of Protein Depolymerization Peptidyl-serine Phosphorylation Positive Regulation Of Cell Division Regulation Of Protein Complex Disassembly Spindle Organization Response To UV Cellular Response To Radiation Maintenance Of Protein Location In Cell Regulation Of Microtubule Cytoskeleton Organization Regulation Of Protein Binding Maintenance Of Protein Location Maintenance Of Location In Cell Negative Regulation Of Cytoskeleton Organization
Tagcloud ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Difference) ?		allele birc5 cdca8 consortium contribution cpc division european exon familial fifteen fixed genotyped incenp inherited investigates meta modest passenger pivotal rs1675126 rs2071214 snp snps spite sporadic synonymous top variability
Tagcloud (Intersection) ?