LATS1 and WWP1

Number of citations: 37 (PubMedID 24107629)
Data Source: BioGRID (unspecified method)

		LATS1	WWP1
Name		large tumor suppressor kinase 1	WW domain containing E3 ubiquitin protein ligase 1
Structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell
Pathways		Signaling by Hippo	Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Subcortical volume (MOSTest) ( 32665545 ) Testicular germ cell tumor ( 28604728 )	Estimated glomerular filtration rate ( 31152163 )
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638
Entrez ID		9113	11059
HPRD ID		09147	03811
Ensembl ID		ENSG00000131023	ENSG00000123124
Uniprot IDs		O95835	Q9H0M0
PDB IDs		4ZRK 5B5W 5BRK 7LWH	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
GO Terms Enriched among Interactors		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process