LATS1 and WWOX

Number of citations of the paper that reports this interaction (PMID 24107629)
5

Data Source:
BioGRID (unspecified method)

		LATS1	WWOX
Gene Name		large tumor suppressor kinase 1	WW domain containing oxidoreductase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Microvillus RNA Polymerase II Transcription Factor Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	RNA Polymerase II Transcription Coactivator Activity Protein Binding Oxidoreductase Activity Enzyme Binding Protein Dimerization Activity Cofactor Binding Coenzyme Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Osteoblast Differentiation Steroid Metabolic Process Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Oxidation-reduction Process Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by Hippo	Nuclear signaling by ERBB4 Signaling by ERBB4
Drugs
Diseases
GWAS			Anorexia nervosa ( 23568457) Cardiac structure and function ( 19584346) Metabolite levels (5-HIAA) ( 23319000) Obesity ( 21552555) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Radiation response ( 20923822) Reasoning ( 21107309) Response to amphetamines ( 22952603) Type 2 diabetes ( 22158537)
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	17 interactors: CPSF2 CPSF7 EZR FIP1L1 HNRNPK LATS1 MAPK8 NUDT21 SF3B3 SRC TCERG1 TNK2 TP53 TP73 UBB WDR33 WIPF2
Entrez ID		9113	51741
HPRD ID		09147	05501
Ensembl ID		ENSG00000131023	ENSG00000186153
Uniprot IDs		O95835	Q9NZC7
PDB IDs			1WMV
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	MRNA Processing MRNA Metabolic Process Transcription From RNA Polymerase II Promoter RNA Processing MRNA 3'-end Processing Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA 3'-end Processing MRNA Polyadenylation Protein Tetramerization RNA Metabolic Process RNA Polyadenylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Termination Of RNA Polymerase II Transcription Gene Expression RNA Splicing Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Phosphorylation DNA-templated Transcription, Termination DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Modification Process Fc Receptor Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Hypoxia Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Cellular Response To Decreased Oxygen Levels Positive Regulation Of Gene Expression Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Protein Metabolic Process MRNA Cleavage Regulation Of Protein Phosphorylation
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	breaks crosstalk cyclopamine ectopically gbm gli glioblastoma h2ax hedgehog impairing ionizing mtp53 multiforme oxidoreductase possessing radiosensitivity sensitize shh smo smoothened sonic u373mg u87mg verify warrants wox1 wtp53 zerumbone
Tagcloud (Intersection) ?