LATS1 and MAP3K2

Number of citations of the paper that reports this interaction (PubMedID 33571521)
55

Data Source:
BioGRID (enzymatic study)

		LATS1	MAP3K2
Description		large tumor suppressor kinase 1	mitogen-activated protein kinase kinase kinase 2
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	MAPK Cascade Intracellular Signal Transduction Cellular Response To Mechanical Stimulus
Pathways		Signaling by Hippo
Drugs		Fostamatinib	Bosutinib Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Protein C levels ( 28082259)
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	27 interacting genes: BIRC2 CTNNB1 IKBKG ITCH LATS1 MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NFKBIA PIBF1 PKN2 SH2D2A SMURF1 SMYD3 STAMBP STUB1 USP2 WNK1 XIAP YAP1 YWHAE YWHAG YWHAZ
Entrez ID		9113	10746
HPRD ID		09147	10068
Ensembl ID		ENSG00000131023	ENSG00000169967
Uniprot IDs		O95835	Q9Y2U5
PDB IDs		4ZRK 5B5W 5BRK 7LWH	2CU1 2NPT 5EX0 5HQ8 6LDV 6LDW 6LDX 6LDY
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	Intracellular Signal Transduction MAPK Cascade Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Stress Signal Transduction Protein Modification Process Positive Regulation Of Protein Metabolic Process Cytosol Protein Polyubiquitination Cytoplasm Regulation Of Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Transferase Activity Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Post-translational Protein Modification Protein Serine Kinase Activity Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway MAP Kinase Kinase Activity Protein Phosphatase Binding Protein Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Immune Response Response To Stress Immune Response-regulating Signaling Pathway Regulation Of Protein Modification Process Regulation Of Immune System Process Positive Regulation Of Signal Transduction Cellular Senescence Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Protein Kinase Activity Stress-activated Protein Kinase Signaling Cascade Phosphoserine Residue Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Modification-dependent Protein Catabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
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