WWP1 and LZTR1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		WWP1	LZTR1
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	leucine-zipper-like transcription regulator 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Sequence-specific DNA Binding Transcription Factor Activity
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	50 interactors: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 IKBKG KDM2B L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		11059	8216
HPRD ID		03811	08992
Ensembl ID		ENSG00000123124	ENSG00000099949
Uniprot IDs		Q9H0M0	Q8N653
PDB IDs		1ND7 2OP7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Chromatin Organization Viral Process Negative Regulation Of Cellular Metabolic Process Cellular Process Positive Regulation Of Metabolic Process Regulation Of Viral Transcription Chromatin Modification DNA-templated Transcription, Elongation Chromatin Remodeling Positive Regulation Of Viral Transcription
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous
Tagcloud (Intersection) ?