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WWP1 and TRAF4
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
WWP1
TRAF4
Description
WW domain containing E3 ubiquitin protein ligase 1
TNF receptor associated factor 4
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Extracellular Exosome
Anchoring Junction
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Bicellular Tight Junction
Membrane
Perinuclear Region Of Cytoplasm
Anchoring Junction
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Central Nervous System Development
Protein Ubiquitination
Monoatomic Ion Transmembrane Transport
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-templated Transcription
Symbiont Entry Into Host Cell
Immune System Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Respiratory Gaseous Exchange By Respiratory System
Respiratory Tube Development
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Pathways
Downregulation of ERBB4 signaling
Stimuli-sensing channels
Regulation of RUNX2 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
)
Interacting Genes
59 interacting genes:
ASH2L
ATN1
CBL
CDKN1B
CLCN5
CPSF6
DAG1
DAZAP2
DIDO1
ENTREP1
EWSR1
FBXL18
HSPB1
IKBKG
IL2RG
IL6R
KLF2
LAPTM5
LATS1
LNX1
LZTR1
MACROH2A2
MIR19A
MIR19B1
NFE2
NOTCH1
PCBD1
PHF20L1
PRKAA2
PRRG4
PTEN
PYGM
RASA1
RNF11
RTN4
RUNX1
SCNN1A
SFTPC
SHANK3
SLC2A1
SMAD3
SMAD5
STAT6
TFAP2A
TGIF1
TP53
TP53BP2
TRAF4
TXNIP
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2L3
WASL
WBP1
WBP2
YWHAQ
ZNF638
137 interacting genes:
ABI3
ACTMAP
ALKBH4
ANXA1
AR
ATOSB
ATOX1
BACH2
BAHD1
BANP
BCKDK
BCL6B
BEGAIN
BEX3
BYSL
CALCOCO2
CAV1
CBL
CBLC
CCHCR1
CENPE
CEP85
CHEK1
CHUK
DISC1
DNM2
DPEP2NB
DTX3
EXOC7
EYA2
EZHIP
FAM90A1
FAT1
FBXL18
FRS3
FTH1
GOLGA2
GOLGA6A
GOLGA6L9
GORASP1
GORASP2
GPRASP1
HEY2
HGS
HMG20A
HOMEZ
HOXA1
HOXB5
IRAK1
IRS1
ISYNA1
KANK2
KANSL1
KDM1A
KRT31
KRT36
LENG8
LNX1
LTBR
MAGEC2
MAGED1
MAP3K4
MRPL28
NCF1
NGFR
NHERF2
NOS1AP
NPAS2
NTRK1
NUDT16L1
OGT
PCSK5
PDE4DIP
PHLDA1
PICK1
PKD1P1
PLAGL2
PLEKHA7
PLSCR1
POLR2J
POLR2J3
PSMC3
QARS1
RAD54L2
RBPMS
REXO1L6P
RNF114
RNF144B
RNF4
RPS6KB1
SF3B4
SIGLEC7
SMURF1
SMURF2
SNRPB
SORBS2
SPDL1
SUMO1
TARBP2
TAX1BP1
TBC1D7
TBC1D8
TFAP4
TGFB1I1
TICAM1
TNFRSF4
TP53BP2
TRAF6
TRIM27
TRIM37
TSGA10IP
TYK2
UBC
UBE2D1
UBE2I
UBL4A
UBL4B
USP7
VPS52
WBP11
WWP1
WWP2
ZBTB16
ZBTB26
ZC3H12C
ZMYM5
ZNF177
ZNF275
ZNF3
ZNF512B
ZNF559-ZNF177
ZNF581
ZNF620
ZNF688
ZNF784
ZNF835
ZRANB1
Entrez ID
11059
9618
HPRD ID
03811
03915
Ensembl ID
ENSG00000123124
ENSG00000076604
Uniprot IDs
Q9H0M0
Q9BUZ4
PDB IDs
1ND7
2OP7
5HPS
5HPT
6J1X
6J1Y
8EI4
9EQK
2EOD
2YUC
3ZJB
4K8U
4M4E
5YC1
Enriched GO Terms of Interacting Partners
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WW Domain Binding
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleoplasm
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Organ Growth
Regulation Of Extracellular Matrix Assembly
Regulation Of DNA-templated Transcription
Response To Hormone
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Metabolic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Regulation Of Developmental Process
Regulation Of Signal Transduction
Cell Fate Commitment
Positive Regulation Of Biosynthetic Process
Regulation Of Extracellular Matrix Organization
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Multicellular Organismal Development
Modification-dependent Protein Catabolic Process
Identical Protein Binding
Negative Regulation Of DNA-templated Transcription
Ubiquitin Conjugating Enzyme Activity
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Apoptotic Process
Nucleus
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Developmental Process
Apoptotic Process
Ubiquitin Ligase Activator Activity
Enzyme Binding
Regulation Of Protein Metabolic Process
Protein Binding
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification Process
Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cytosol
Protein Modification By Small Protein Conjugation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Protein Ubiquitination
Regulation Of Transcription By RNA Polymerase II
Ubiquitin-protein Transferase Activity
Regulation Of Gene Expression
Ubiquitin Protein Ligase Activity
Post-translational Protein Modification
Negative Regulation Of RNA Metabolic Process
Modification-dependent Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Surface Toll-like Receptor Signaling Pathway
Identical Protein Binding
Ubiquitin-dependent Protein Catabolic Process
Protein Metabolic Process
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Cytoplasm
Positive Regulation Of Metabolic Process
Regulation Of Protein Modification Process
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
PML Body
Regulation Of Programmed Cell Death
Negative Regulation Of Macromolecule Biosynthetic Process
Signaling Adaptor Activity
Zinc Ion Binding
Proteolysis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Macromolecule Catabolic Process
Positive Regulation Of Protein Metabolic Process
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