LATS1 and PTEN

Number of citations of the paper that reports this interaction (PMID 22641346)
5

Data Source:
BioGRID (enzymatic study)

		LATS1	PTEN
Gene Name		large tumor suppressor kinase 1	phosphatase and tensin homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane PML Body Myelin Sheath Adaxonal Region Cell Projection Neuron Projection Dendritic Spine Schmidt-Lanterman Incisure Postsynaptic Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Magnesium Ion Binding Phosphatidylinositol-3-phosphatase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Lipid Binding Anaphase-promoting Complex Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Enzyme Binding Protein Kinase Binding PDZ Domain Binding Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Angiogenesis Negative Regulation Of Protein Phosphorylation Regulation Of B Cell Apoptotic Process Protein Dephosphorylation Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Apoptotic Process Activation Of APC-Cdc20 Complex Activity Epidermal Growth Factor Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Synapse Assembly Central Nervous System Development Heart Development Aging Response To Nutrient Learning Or Memory Memory Locomotory Behavior Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Glucose Response To Zinc Ion Regulation Of Neuron Projection Development Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Dentate Gyrus Development Central Nervous System Neuron Axonogenesis Negative Regulation Of Cell Migration Negative Regulation Of Myelination Regulation Of Protein Stability Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Central Nervous System Myelin Maintenance Response To Estradiol Regulation Of Cellular Component Size Regulation Of Myeloid Cell Apoptotic Process Response To ATP Multicellular Organismal Response To Stress Social Behavior Peptidyl-tyrosine Dephosphorylation Fc-epsilon Receptor Signaling Pathway Response To Drug Maternal Behavior Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Endothelial Cell Migration Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Innate Immune Response Response To Ethanol Locomotor Rhythm Negative Regulation Of Cell Size Negative Regulation Of Organ Growth Response To Arsenic-containing Substance Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cardiac Muscle Tissue Development Forebrain Morphogenesis Brain Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Phagocytosis Negative Regulation Of Axonogenesis Protein Stabilization T Cell Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Kinase B Signaling Rhythmic Synaptic Transmission Canonical Wnt Signaling Pathway Synapse Maturation Prepulse Inhibition Male Mating Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Prostate Gland Growth Dendritic Spine Morphogenesis Negative Regulation Of Dendritic Spine Morphogenesis Negative Regulation Of Ribosome Biogenesis Negative Regulation Of Cell Aging Negative Regulation Of Excitatory Postsynaptic Membrane Potential Presynaptic Membrane Assembly Postsynaptic Density Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Excitatory Postsynaptic Membrane Potential Negative Regulation Of Synaptic Vesicle Clustering Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by Hippo	Signaling by the B Cell Receptor (BCR) Downstream TCR signaling Metabolism of lipids and lipoproteins Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Synthesis of PIPs at the plasma membrane Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Synthesis of IP3 and IP4 in the cytosol PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Phospholipid metabolism PI Metabolism Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Negative regulation of the PI3K/AKT network Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Inositol phosphate metabolism PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR TCR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	34 interactors: AKT1 ANG AR CAV1 CDC27 CHGB COPS6 CSNK2A1 CSNK2A2 DLG1 ESR1 FZR1 HBA1 LATS1 MAGI2 MAGI3 MAST1 MAST2 MAST3 MVP NDFIP1 NEDD4 PARK7 PPP1CA PXN SLC9A3R1 SLC9A3R2 STK11 TP53 UBE2I UBE2L3 USP13 UTP14A WWP1
Entrez ID		9113	5728
HPRD ID		09147	03431
Ensembl ID		ENSG00000131023
Uniprot IDs		O95835	F6KD01 P60484
PDB IDs			1D5R 2KYL
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Negative Regulation Of Signaling Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cell Cycle Process Negative Regulation Of Signal Transduction Cell Cycle Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Metabolic Process Positive Regulation Of Phosphorylation Mitotic Cell Cycle Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Protein Complex Assembly Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Protein Catabolic Process Protein Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Negative Regulation Of Protein Metabolic Process Cell Communication Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Ubiquitin-dependent Protein Catabolic Process Catabolic Process Regulation Of Protein Ubiquitination Modification-dependent Protein Catabolic Process
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	10q already ath aths atypical bax carcinogenesis ec ecs endometrial frequencies hyperplasias igfiir instability lead lesions lohs microsatellite msis mutated mutations pathogenesis precursor premalignant pursue putative rii simple tgf
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	10q already ath aths atypical bax carcinogenesis ec ecs endometrial frequencies hyperplasias igfiir instability lead lesions lohs microsatellite msis mutated mutations pathogenesis precursor premalignant pursue putative rii simple tgf
Tagcloud (Intersection) ?