WWP1 and IL2RG

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		WWP1	IL2RG
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	interleukin 2 receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		11059	3561
HPRD ID		03811	02391
Ensembl ID		ENSG00000123124	ENSG00000147168
Uniprot IDs		Q9H0M0	P31785 Q5FC09
PDB IDs		1ND7 2OP7	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?