WWP1 and SCNN1A

Number of citations of the paper that reports this interaction (PMID 14556380)
1

Data Source:
BioGRID (two hybrid)

		WWP1	SCNN1A
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	sodium channel, non voltage gated 1 alpha subunit
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Cortical Actin Cytoskeleton Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Actin Binding Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis Transmembrane Transport
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System	Ion channel transport Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases
GWAS			Obesity (early onset extreme) ( 23563609)
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	16 interactors: CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		11059	6337
HPRD ID		03811	02575
Ensembl ID		ENSG00000123124	ENSG00000111319
Uniprot IDs		Q9H0M0	F5GXE6 P37088
PDB IDs		1ND7 2OP7	2M3O
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Viral Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Catabolic Process Viral Life Cycle Proteolysis Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Sodium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Catabolic Process Interaction With Host Cellular Protein Modification Process Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Viral Entry Into Host Cell Entry Into Host Cell Excretion Protein Polyubiquitination Regulation Of Signaling Regulation Of Potassium Ion Transport Water Homeostasis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Cellular Metabolic Process Regulation Of Membrane Potential Regulation Of Cellular Localization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Ion Transmembrane Transporter Activity Negative Regulation Of Transport Regulation Of Transmembrane Transporter Activity Regulation Of Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	aldosterone atp1a1 atpasealpha1 betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption stepwise synergy transcriptomic
Tagcloud (Intersection) ?