LATS1 and FOXL2

Number of citations of the paper that reports this interaction (PMID 20407010)
5

Data Source:
BioGRID (enzymatic study)

		LATS1	FOXL2
Gene Name		large tumor suppressor kinase 1	forkhead box L2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Nucleus
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Estrogen Receptor Binding Ubiquitin Conjugating Enzyme Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Sequence-specific DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovarian Follicle Development Extraocular Skeletal Muscle Development Apoptotic DNA Fragmentation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Female Somatic Sex Determination Cell Differentiation Menstruation Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Eye Morphogenesis Granulosa Cell Differentiation
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS			Keloid ( 20711176)
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	3 interactors: LATS1 PAK1 SUMO1
Entrez ID		9113	668
HPRD ID		09147	05723
Ensembl ID		ENSG00000131023	ENSG00000183770
Uniprot IDs		O95835	P58012 Q53ZD3
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Localization PML Body Organization Cellular Response To Organic Substance Positive Regulation Of Cellular Component Biogenesis Protein Localization Regulation Of Cellular Component Organization Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Actin Cytoskeleton Organization Protein Localization To Nuclear Pore Protein Localization To Membrane Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein Localization To Nuclear Envelope Histone H3-T11 Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Actin Filament-based Process Cellular Localization Response To Organic Substance Regulation Of Cellular Ketone Metabolic Process Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Metabolic Process Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Signaling Organelle Organization Cellular Protein Modification Process Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Response To Interferon-gamma Regulation Of Protein Kinase Activity Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hyperosmotic Response Positive Regulation Of Metabolic Process Cytoplasmic Sequestering Of Protein Protein Sumoylation Regulation Of Kinase Activity Regulation Of Protein Localization Hippo Signaling Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Membrane Organization Positive Regulation Of Phosphorylation
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	4x180k benthic bioassays caeruleum customized cyp11a cyp19a1 darter disruptions dmrt1 effluent effluents esrb etheostoma gonad grand hatching intersex mwwes oogenesis outfalls ovulation pollutant polluted rainbow rbd spermatid suite vtg
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	4x180k benthic bioassays caeruleum customized cyp11a cyp19a1 darter disruptions dmrt1 effluent effluents esrb etheostoma gonad grand hatching intersex mwwes oogenesis outfalls ovulation pollutant polluted rainbow rbd spermatid suite vtg
Tagcloud (Intersection) ?