LATS1 and FOXL2

Number of citations of the paper that reports this interaction (PubMedID 20407010)
60

Data Source:
BioGRID (enzymatic study)

		LATS1	FOXL2
Description		large tumor suppressor kinase 1	forkhead box L2
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Flemming Body
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Estrogen Receptor Binding Ubiquitin Conjugating Enzyme Binding Cysteine-type Endopeptidase Regulator Activity Involved In Apoptotic Process Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Oocyte Growth Extraocular Skeletal Muscle Development Apoptotic DNA Fragmentation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Single Fertilization Female Gonad Development Anatomical Structure Morphogenesis Female Somatic Sex Determination Cell Differentiation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Follicle-stimulating Hormone Secretion Embryonic Eye Morphogenesis Granulosa Cell Differentiation Uterus Development
Pathways		Signaling by Hippo	SUMOylation of transcription factors
Drugs		Fostamatinib
Diseases			Premature ovarian failure Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES)
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Ear morphology ( 26105758) Eyebrow thickness ( 26926045 30248107) Keloid ( 20711176) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Lobe size ( 26105758) Male-pattern baldness ( 28196072)
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	3 interacting genes: LATS1 PAK1 UBE2I
Entrez ID		9113	668
HPRD ID		09147	05723
Ensembl ID		ENSG00000131023	ENSG00000183770
Uniprot IDs		O95835	P58012 Q53ZD3
PDB IDs		4ZRK 5B5W 5BRK 7LWH	7VOU 7VOV
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Organ Growth Chromosome Segregation SUMO Conjugating Enzyme Activity ATP Binding Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein-containing Complex Assembly RING-like Zinc Finger Domain Binding Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Actin Filament Organization SUMO Ligase Complex HLH Domain Binding Positive Regulation Of Signal Transduction Nucleotide Binding Regulation Of Developmental Growth Transferase Activity Small Protein Activating Enzyme Binding Positive Regulation Of Microtubule Nucleation Protein Serine Kinase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Regulation Of Actin Filament-based Process Protein Localization To Cytoplasmic Stress Granule Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Supramolecular Fiber Organization Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Nuclear Membrane Reassembly Regulation Of Protein-containing Complex Assembly Positive Regulation Of Locomotion Regulation Of Microtubule Nucleation Positive Regulation Of Cellular Component Biogenesis Protein Kinase Binding Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Growth Positive Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Insulin Receptor Signaling Pathway Kinase Activity Cellular Response To Lectin Protein Kinase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
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