LATS1 and MAP4K4

Number of citations: 89 (PubMedID 35027733)
Data Source: BioGRID (enzymatic study)

		LATS1	MAP4K4
Name		large tumor suppressor kinase 1	mitogen-activated protein kinase kinase kinase kinase 4
Structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Cytoplasm Focal Adhesion
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Creatine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of ARF Protein Signal Transduction Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Intracellular Signal Transduction
Pathways		Signaling by Hippo	Oxidative Stress Induced Senescence
Drugs		Fostamatinib	Fostamatinib
GWAS		Brain morphology (MOSTest) ( 32665545 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Subcortical volume (MOSTest) ( 32665545 ) Testicular germ cell tumor ( 28604728 )	Alzheimer's disease ( 30636644 ) Asthma ( 31619474 ) Asthma (time to onset) ( 27130862 ) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) White blood cell count ( 32888494 )
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	27 interacting genes: BRCA1 CASP8 CTTNBP2NL DOK1 DSCAM GBP3 H2BC21 ITGB1 KIF26B KIF5A LATS1 MAP3K7 MOB4 NCK1 NME7 PPP1CA PPP1CC PPP2CA PRKCE PTK2B RAP2A RASA1 RIPPLY3 SLC9A1 STRIP1 STRN4 TBPL2
Entrez ID		9113	9448
HPRD ID		09147	05235
Ensembl ID		ENSG00000131023	ENSG00000071054
Uniprot IDs		O95835	B7Z3V5 E7EN19 G5E948 O95819 V9HWH3
PDB IDs		4ZRK 5B5W 5BRK 7LWH	4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q 8V5I
GO Terms Enriched among Interactors		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	FAR/SIN/STRIPAK Complex Regulation Of Hippo Signaling Regulation Of Intracellular Signal Transduction Regulation Of Cytoskeleton Organization Negative Regulation Of Hippo Signaling Regulation Of Supramolecular Fiber Organization Cytoplasm Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Organization Regulation Of Actin Filament Length Regulation Of Cellular Component Size RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Lamellipodium Protein Dephosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Glutamatergic Synapse Protein-macromolecule Adaptor Activity Regulation Of Actin Filament-based Process Postsynapse Positive Regulation Of Locomotion Negative Regulation Of Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Cell Communication Regulation Of Organelle Organization Negative Regulation Of Signaling Dephosphorylation PTW/PP1 Phosphatase Complex Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Signaling Receptor Activator Activity Dendritic Spine Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Synapse Organization Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Cellular Component Biogenesis Gamma-tubulin Ring Complex Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Process Phosphate-containing Compound Metabolic Process Regulation Of Locomotion Positive Regulation Of Programmed Cell Death