LATS1 and LOXL2

Number of citations: 0 (PubMedID 35271888)
Data Source: BioGRID (enzymatic study)

		LATS1	LOXL2
Name		large tumor suppressor kinase 1	lysyl oxidase like 2
Structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Chromatin Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Chromosome Endoplasmic Reticulum Membrane Extracellular Matrix
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Protein-lysine 6-oxidase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Metal Ion Binding Oligosaccharide Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Epithelial To Mesenchymal Transition Endothelial Cell Proliferation Sprouting Angiogenesis Chromatin Organization Positive Regulation Of Epithelial To Mesenchymal Transition Peptidyl-lysine Oxidation Collagen Fibril Organization Positive Regulation Of Chondrocyte Differentiation Protein Modification Process Endothelial Cell Migration Negative Regulation Of DNA-templated Transcription Response To Copper Ion Heterochromatin Organization Negative Regulation Of Stem Cell Population Maintenance
Pathways		Signaling by Hippo	Elastic fibre formation Crosslinking of collagen fibrils
Drugs		Fostamatinib	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Nicotine dependence and major depression (severity of comorbidity) ( 30287806 ) Subcortical volume (MOSTest) ( 32665545 ) Testicular germ cell tumor ( 28604728 )	Appendicular lean mass ( 33097823 ) Attention deficit hyperactivity disorder ( 20732625 ) Central corneal thickness ( 29760442 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31562340 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	3 interacting genes: DAPK1 HSP90AA1 LATS1
Entrez ID		9113	4017
HPRD ID		09147	09446
Ensembl ID		ENSG00000131023	ENSG00000134013
Uniprot IDs		O95835	Q9Y4K0
PDB IDs		4ZRK 5B5W 5BRK 7LWH	5ZE3
GO Terms Enriched among Interactors		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	ATP Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of NMDA Receptor Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Component Size Rho GDP-dissociation Inhibitor Binding CTP Binding DATP Binding Positive Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Regulation Of Protein Localization To Nucleus Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Sperm Mitochondrial Sheath Nucleotide Binding Phosphorylation Cellular Response To Hydroperoxide Protein Serine Kinase Activity Protein Phosphorylation GTP Binding Protein Serine/threonine Kinase Activity Chaperone-mediated Autophagy Positive Regulation Of Cardiac Muscle Contraction Nitric-oxide Synthase Regulator Activity Chromosome Organization Inclusion Body Assembly Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Defense Response To Tumor Cell Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Kinase Activity Positive Regulation Of Cell Size Protein Unfolding Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Kinase Activity Positive Regulation Of Apoptotic Process Protein Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Positive Regulation Of Catabolic Process Glutamatergic Synapse