WWP1 and TP53BP2

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		WWP1	TP53BP2
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	tumor protein p53 binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Cell Cycle Signal Transduction Central Nervous System Development Heart Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Signal Transduction Response To Ionizing Radiation Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	58 interactors: APP ATPAF2 ATXN7 BAIAP2 BCL2 BCL2L1 CCDC92 CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 HIST1H2BC HNRNPUL1 KIF5A LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRKAB2 PRPF31 PTN RELA SIAH1 SIAH2 SSX2IP SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26
Entrez ID		11059	7159
HPRD ID		03811	11803
Ensembl ID		ENSG00000123124	ENSG00000143514
Uniprot IDs		Q9H0M0	Q13625
PDB IDs		1ND7 2OP7	1YCS 2UWQ 4A63
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Neuron Death Neuron Apoptotic Process Response To Radiation Regulation Of Signal Transduction Regulation Of Signaling Response To External Stimulus Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Signaling Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Apoptotic Signaling Pathway Cell Part Morphogenesis Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Metabolic Process Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Phosphorylation Response To Light Stimulus Protein Modification By Small Protein Conjugation Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Cycle Neuron Projection Morphogenesis Regulation Of Mitochondrion Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Projection Morphogenesis Axonogenesis Cellular Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Cell Morphogenesis Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Protein Metabolic Process Response To Gamma Radiation Axon Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Generation Of Neurons Nervous System Development Cellular Response To Ionizing Radiation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Innate Immune Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Neuron Projection Development Neurogenesis Anatomical Structure Morphogenesis
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	adenovirus angiotensin apoptosis array at2r bag3 bmp6 bmp7 bnipi cytokine downregulation du145 gadd45a hrk il6 il8 mapk microrna next numerous p44 pc r2 silence sirnas tnfsf10 trail transduced utilized
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	adenovirus angiotensin apoptosis array at2r bag3 bmp6 bmp7 bnipi cytokine downregulation du145 gadd45a hrk il6 il8 mapk microrna next numerous p44 pc r2 silence sirnas tnfsf10 trail transduced utilized
Tagcloud (Intersection) ?