LATS1 and NUAK1

Number of citations of the paper that reports this interaction (PMID 19927127)
13

Data Source:
BioGRID (enzymatic study)

		LATS1	NUAK1
Gene Name		large tumor suppressor kinase 1	NUAK family, SNF1-like kinase, 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Nucleus Nucleolus Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Regulation Of Cell Proliferation Regulation Of Cellular Senescence
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS			Alzheimer's disease biomarkers ( 23419831)
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	6 interactors: APP CASP6 FBXO25 LATS1 PPP1CC UBC
Entrez ID		9113	9891
HPRD ID		09147	12171
Ensembl ID		ENSG00000131023	ENSG00000074590
Uniprot IDs		O95835	O60285
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Glycogen Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Regulation Of ERBB Signaling Pathway Polysaccharide Metabolic Process Cellular Protein Modification Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Energy Reserve Metabolic Process Notch Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Negative Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Cellular Carbohydrate Metabolic Process Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Death Death Axon Choice Point Recognition Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	4e actin actual antilung bp1 chemotaxis contrarily downregulating downregulation excessively hypermethylation invasion invasiveness log luciferase manipulate manipulated matrigel mir mir204 nsclc p70s6k1 polymerisation protein1 rank repress scratch upregulation utr
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	4e actin actual antilung bp1 chemotaxis contrarily downregulating downregulation excessively hypermethylation invasion invasiveness log luciferase manipulate manipulated matrigel mir mir204 nsclc p70s6k1 polymerisation protein1 rank repress scratch upregulation utr
Tagcloud (Intersection) ?