LATS1 and ALPP

Number of citations of the paper that reports this interaction (PMID 22641346)
5

Data Source:
BioGRID (enzymatic study)

		LATS1	ALPP
Gene Name		large tumor suppressor kinase 1	alkaline phosphatase, placental
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Plasma Membrane Cell Surface Integral Component Of Membrane Anchored Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Magnesium Ion Binding Alkaline Phosphatase Activity Zinc Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Dephosphorylation
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS			Height ( 19570815)
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	7 interactors: ALPPL2 GPLD1 KRTAP10-3 KRTAP4-12 KRTAP5-9 LATS1 PIGK
Entrez ID		9113	250
HPRD ID		09147	01379
Ensembl ID		ENSG00000131023	ENSG00000163283
Uniprot IDs		O95835	P05187
PDB IDs			1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	GPI Anchor Metabolic Process GPI Anchor Release Cellular Response To Triglyceride Glycolipid Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Positive Regulation Of Cytolysis Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Complement Receptor Mediated Signaling Pathway Phosphate-containing Compound Metabolic Process Epidermis Development Response To Triglyceride Glycerophospholipid Metabolic Process Attachment Of GPI Anchor To Protein Glycerolipid Metabolic Process Phospholipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To PH Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Cellular Response To Cholesterol Tissue Development Cellular Response To Sterol Regulation Of Triglyceride Biosynthetic Process Cell Migration Involved In Sprouting Angiogenesis Response To Cholesterol Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Lipid Catabolic Process Cytoplasmic Sequestering Of Protein Hippo Signaling Cellular Response To Hormone Stimulus C-terminal Protein Lipidation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Protein Transport Positive Regulation Of Phosphatase Activity Blood Vessel Endothelial Cell Migration Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Regulation Of Establishment Of Protein Localization Response To PH
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	adsc adscs buffered capacities coinjection encapsulated ganglia glycolic intramuscularly lactic leak masson microspheres nerves ngf pbs periurethral plga pnt pudendal reassessed retrograde rupp sui transection trichrome trk urethra urodynamic
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours	adsc adscs buffered capacities coinjection encapsulated ganglia glycolic intramuscularly lactic leak masson microspheres nerves ngf pbs periurethral plga pnt pudendal reassessed retrograde rupp sui transection trichrome trk urethra urodynamic
Tagcloud (Intersection) ?