WWP1 and CLCN5

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		WWP1	CLCN5
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	chloride channel, voltage-sensitive 5
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Golgi Membrane Lysosomal Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Part Of Cell
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Voltage-gated Chloride Channel Activity Chloride Channel Activity ATP Binding Antiporter Activity
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Transport Endocytosis Excretion Ion Transmembrane Transport Regulation Of Anion Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System	Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	4 interactors: CFL1 MAGI1 WWP1 WWP2
Entrez ID		11059	1184
HPRD ID		03811	02053
Ensembl ID		ENSG00000123124	ENSG00000171365
Uniprot IDs		Q9H0M0	A8K4H5 B3KRR2 P51795
PDB IDs		1ND7 2OP7	2J9L 2JA3
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Viral Entry Into Host Cell Entry Into Host Cell Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Viral Life Cycle Locomotion Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Cell Size Neural Fold Formation Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Modification-dependent Protein Catabolic Process Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transport Positive Regulation Of Protein Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Potassium Ion Transmembrane Transporter Activity Morphogenesis Of An Epithelial Fold Protein K63-linked Ubiquitination Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Transmembrane Transport Mitotic Cytokinesis Negative Regulation Of Transporter Activity Protein Autoubiquitination Cellular Macromolecule Catabolic Process Neural Crest Cell Migration Regulation Of Dendritic Spine Development Cellular Protein Modification Process Negative Regulation Of ERK1 And ERK2 Cascade
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	3a a249fs aberrantly addictive dent digenic dysmorphic epistatic expressivity inheritance inositol interfamilial intrafamilial keeping leukocytes lowe modifier mother ocrl retardation rhogap rickets skewed skipping splice spliced surmise truncating tubulopathy
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	3a a249fs aberrantly addictive dent digenic dysmorphic epistatic expressivity inheritance inositol interfamilial intrafamilial keeping leukocytes lowe modifier mother ocrl retardation rhogap rickets skewed skipping splice spliced surmise truncating tubulopathy
Tagcloud (Intersection) ?