WWP1 and CLCN5

Number of citations of the paper that reports this interaction (PubMedID 9169421)
0

Data Source:
HPRD (in vitro)

		WWP1	CLCN5
Description		WW domain containing E3 ubiquitin protein ligase 1	chloride voltage-gated channel 5
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction	Golgi Membrane Lysosomal Membrane Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Membrane Apical Part Of Cell
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell	Renal System Process Monoatomic Ion Transport Chloride Transport Endocytosis Monoatomic Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Stimuli-sensing channels
Drugs
Diseases			Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypophosphatemic rickets; Low-molecular-weight proteinuria with hypercalciuria and nephrocalcinosis
GWAS		Estimated glomerular filtration rate ( 31152163)	Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Red blood cell count ( 32888494)
Interacting Genes		59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	4 interacting genes: CFL1 MAGI1 WWP1 WWP2
Entrez ID		11059	1184
HPRD ID		03811	02053
Ensembl ID		ENSG00000123124	ENSG00000171365
Uniprot IDs		Q9H0M0	A8K4H5 B3KRR2 P51795 V9GYG7
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK	2J9L 2JA3
Enriched GO Terms of Interacting Partners?		WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process	Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Cofilin-actin Rod Cell Leading Edge Negative Regulation Of Unidimensional Cell Growth Positive Regulation Of Establishment Of Cell Polarity Regulating Cell Shape Positive Regulation Of Barbed-end Actin Filament Capping Positive Regulation Of Protein Localization To Cell Leading Edge C-X-C Motif Chemokine 12 Receptor Activity Anchoring Junction Ubiquitin Ligase Complex Negative Regulation Of Postsynaptic Density Organization Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Protein Localization To Cell Leading Edge Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Cell Adhesion Extracellular Exosome Neural Fold Formation Actin Filament Fragmentation Negative Regulation Of Dendritic Spine Maintenance Regulation Of Barbed-end Actin Filament Capping Cell-cell Junction Negative Regulation Of Lamellipodium Assembly CXCL12-activated CXCR4 Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Ubiquitin-protein Transferase Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Cell Size Positive Regulation Of Synaptic Plasticity Potassium Channel Inhibitor Activity Positive Regulation Of Actin Filament Depolymerization Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Ether Actin Filament Depolymerization Modification Of Postsynaptic Actin Cytoskeleton Phosphatidylinositol Bisphosphate Binding Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Dendritic Spine Maintenance Actin Filament Severing Endothelial Cell Morphogenesis Ubiquitin Protein Ligase Activity Morphogenesis Of An Epithelial Fold Myelin Maintenance Alpha-actinin Binding Actin Binding Cellular Response To Interleukin-6 Response To Virus
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