WWP1 and KLF2

Number of citations of the paper that reports this interaction (PubMedID 11375995)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		WWP1	KLF2
Description		WW domain containing E3 ubiquitin protein ligase 1	KLF transcription factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction	Chromatin Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6 Production Erythrocyte Homeostasis Response To Laminar Fluid Shear Stress Multicellular Organism Growth Epigenetic Regulation Of Gene Expression Vasodilation Erythrocyte Maturation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Cellular Stress Response To Acid Chemical Negative Regulation Of Sprouting Angiogenesis Cellular Response To Endothelin
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Asthma ( 32296059) Coronary artery disease ( 33020668) Depression in smokers ( 30219690) Diastolic blood pressure ( 30224653) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Systemic lupus erythematosus ( 33493351) White blood cell count ( 32888494)
Interacting Genes		59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	7 interacting genes: EP300 GATA5 GATA6 GSK3B KAT2B PSME3 WWP1
Entrez ID		11059	10365
HPRD ID		03811	03602
Ensembl ID		ENSG00000123124	ENSG00000127528
Uniprot IDs		Q9H0M0	Q9Y5W3
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
Enriched GO Terms of Interacting Partners?		WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process	N-terminal Peptidyl-lysine Acetylation P53 Binding L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation TORC2 Signaling N-terminal Protein Amino Acid Acetylation Striated Muscle Tissue Development Regulation Of Cellular Response To Heat Peptidyl-lysine Acetylation Regulation Of TORC2 Signaling Regulation Of Generation Of Precursor Metabolites And Energy Intestinal Epithelial Cell Differentiation Muscle Tissue Development Acetyltransferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Complex Cell Fate Commitment Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-lysine-acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Histone Acetyltransferase Activity Cellular Response To BMP Stimulus NF-kappaB Binding Protein Acetylation Endodermal Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Rhythmic Process Cellular Response To Stress Heart Development Tau Protein Binding Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Gene Expression, Epigenetic Cellular Response To Oxygen-containing Compound Regulation Of DNA-templated Transcription Regulation Of Glycolytic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling
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