WWP1 and KLF2

Number of citations of the paper that reports this interaction (PMID 11375995)
17

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		WWP1	KLF2
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	Kruppel-like factor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Cell Morphogenesis In Utero Embryonic Development Transcription, DNA-templated Negative Regulation Of Interleukin-6 Production Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression, Epigenetic Erythrocyte Maturation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Cellular Response To Peptide
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	6 interactors: EP300 GATA5 GATA6 GSK3B KAT2B WWP1
Entrez ID		11059	10365
HPRD ID		03811	03602
Ensembl ID		ENSG00000123124	ENSG00000127528
Uniprot IDs		Q9H0M0	Q8IUN4 Q9Y5W3
PDB IDs		1ND7 2OP7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Intestinal Epithelial Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To BMP Stimulus Cellular Response To Organic Substance N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Rhythmic Process Regulation Of RNA Metabolic Process Positive Regulation Of Stem Cell Differentiation Response To Organic Substance Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Heat Positive Regulation Of Protein Binding Negative Regulation Of Biosynthetic Process Muscle Structure Development Viral Process Histone H2B Acetylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Growth Factor Stimulus Regulation Of Glucose Metabolic Process ER-nucleus Signaling Pathway Response To Growth Factor Cellular Response To Oxygen Levels Response To Heat Positive Regulation Of Metabolic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Tissue Development Positive Regulation Of Binding Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Histone H3-K9 Acetylation Negative Regulation Of Type B Pancreatic Cell Development
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	92a ameliorates atherogenesis attenuates bioavailability challenged disrupts dysfunctional ecs enos exacerbates hypercholesterolemic inflammasome infused innate klf4 kruppel lna locked microrna nlrp3 nucleic postulated pyrin sirtuin srebp2 sterol stresses vasodilation
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	92a ameliorates atherogenesis attenuates bioavailability challenged disrupts dysfunctional ecs enos exacerbates hypercholesterolemic inflammasome infused innate klf4 kruppel lna locked microrna nlrp3 nucleic postulated pyrin sirtuin srebp2 sterol stresses vasodilation
Tagcloud (Intersection) ?