WWP1 and FBXL18

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		WWP1	FBXL18
Description		WW domain containing E3 ubiquitin protein ligase 1	F-box and leucine rich repeat protein 18
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell	SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) High light scatter reticulocyte count ( 32888494) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Relative hand skill in reading disability ( 24068947)
Interacting Genes		59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	22 interacting genes: CALCOCO2 FBXL7 FHL3 GOLGA2 HNRNPK KRT40 KRTAP10-3 KRTAP4-12 MDFI MID2 MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSMA3 PSTPIP1 RBPMS TFCP2 TRAF1 TRAF4 WWP1 WWP2
Entrez ID		11059	80028
HPRD ID		03811	07753
Ensembl ID		ENSG00000123124	ENSG00000155034
Uniprot IDs		Q9H0M0	Q96D16 Q96ME1
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK
Enriched GO Terms of Interacting Partners?		WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process	Cytoplasm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Thioesterase Binding Cytoskeleton Proteasomal Protein Catabolic Process Transcription Factor Binding Keratin Filament Ubiquitin Ligase Complex Symbiont Entry Into Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Tumor Necrosis Factor Receptor Binding Identical Protein Binding Biological Process Involved In Interaction With Host Protein Catabolic Process Intermediate Filament Transcription Regulator Inhibitor Activity Proteolysis Involved In Protein Catabolic Process
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