WWP1 and DAG1

Number of citations of the paper that reports this interaction (PMID 9169421)
29

Data Source:
HPRD (in vitro)

		WWP1	DAG1
Gene Name		WW domain containing E3 ubiquitin protein ligase 1	dystroglycan 1 (dystrophin-associated glycoprotein 1)
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Extracellular Space Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Adherens Junction Focal Adhesion Cell Outer Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Node Of Ranvier Sarcolemma Costamere Membrane Raft Postsynaptic Membrane Extracellular Vesicular Exosome Contractile Ring
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity	Virus Receptor Activity Dystroglycan Binding Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding Protein Complex Binding SH2 Domain Binding Laminin-1 Binding Alpha-actinin Binding
	Biological Process	Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Transmembrane Transport	Morphogenesis Of An Epithelial Sheet Membrane Protein Ectodomain Proteolysis NLS-bearing Protein Import Into Nucleus Cytoskeletal Anchoring At Plasma Membrane Response To Virus Calcium-dependent Cell-matrix Adhesion Modulation By Virus Of Host Morphology Or Physiology Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Microtubule Anchoring Negative Regulation Of MAPK Cascade Response To Peptide Hormone Negative Regulation Of Protein Kinase B Signaling Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Commissural Neuron Axon Guidance Basement Membrane Organization
Pathways		Downregulation of ERBB4 signaling Ion channel transport Antigen processing: Ubiquitination & Proteasome degradation Stimuli-sensing channels Class I MHC mediated antigen processing & presentation Signaling by ERBB4 Adaptive Immune System	ECM proteoglycans Integrin cell surface interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		47 interactors: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 H2AFY2 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PTEN RASA1 RNF11 RTN4 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2L3 WBP1 WBP2 YWHAQ ZNF638	25 interactors: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		11059	1605
HPRD ID		03811	00546
Ensembl ID		ENSG00000123124	ENSG00000173402
Uniprot IDs		Q9H0M0	Q14118
PDB IDs		1ND7 2OP7	1EG4
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance RNA Metabolic Process Organ Development Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Apoptotic Process Gene Expression Regulation Of Transcription, DNA-templated Programmed Cell Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Death Death Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter System Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ossification Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Positive Regulation Of Cellular Protein Metabolic Process Tube Development Positive Regulation Of Protein Modification Process Multicellular Organismal Development Negative Regulation Of Signaling Tissue Development Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Response To Growth Factor Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Signal Transduction Developmental Process Positive Regulation Of Ligase Activity Epithelium Development	Locomotion Regulation Of Cell Adhesion Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Axonogenesis Axon Development Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis System Development Neuron Projection Morphogenesis Cell Projection Organization Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Multicellular Organismal Development Positive Regulation Of Cell Adhesion Neuron Projection Development Anatomical Structure Development Cell Development Chemotaxis Negative Regulation Of Peptidyl-serine Phosphorylation Neuron Development Receptor Metabolic Process Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Neuron Differentiation Regulation Of Body Fluid Levels Nervous System Development Leukocyte Migration Wound Healing Cell Adhesion Cell Differentiation Generation Of Neurons Blood Coagulation Hemostasis Neurogenesis Regulation Of Phosphorylation Regulation Of Ion Transmembrane Transporter Activity Response To Wounding Muscle Organ Development Regulation Of Transmembrane Transporter Activity Negative Regulation Of Anoikis Muscle Structure Development Regulation Of Sodium Ion Transport Regulation Of Protein Phosphorylation Regulation Of Anoikis Regulation Of Phosphorus Metabolic Process Cytoskeleton Organization
Tagcloud ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	branches compensates dag1gai dag1rga28 della dof dormancy embryo factor3 ga ga1 gai germination germination1 insensitive lethal master overlapping phytocrome pil5 repressor rga rga28 seed seeds severely surprisingly t6 unexpected
Tagcloud (Difference) ?		biol chem consisting contains e2 ermekova gavva globin gst hematopoietic heterodimer homologue interacted j ligase motifs multimeric p18 p45 phage ppxy sh3 shen spanning sudol tandem transactivation ubiquitous	branches compensates dag1gai dag1rga28 della dof dormancy embryo factor3 ga ga1 gai germination germination1 insensitive lethal master overlapping phytocrome pil5 repressor rga rga28 seed seeds severely surprisingly t6 unexpected
Tagcloud (Intersection) ?