WWP1 and NOTCH1

Number of citations of the paper that reports this interaction (PubMedID 16785210)
0

Data Source:
BioGRID (pull down, imaging technique)

		WWP1	NOTCH1
Description		WW domain containing E3 ubiquitin protein ligase 1	notch receptor 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Anchoring Junction	Golgi Membrane Acrosomal Vesicle MAML1-RBP-Jkappa- ICN1 Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Adherens Junction Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Late Endosome Membrane Receptor Complex Cell Periphery Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Chromatin Binding Transcription Coactivator Activity Enzyme Inhibitor Activity Transmembrane Signaling Receptor Activity Notch Binding Calcium Ion Binding Protein Binding Enzyme Binding Chromatin DNA Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Transcription Regulator Activator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Monoatomic Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Luteolysis In Utero Embryonic Development Epithelial To Mesenchymal Transition Liver Development Heart Looping Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Inhibition Of Neuroepithelial Cell Differentiation Inflammatory Response To Antigenic Stimulus Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Atrioventricular Node Development Coronary Vein Morphogenesis Aortic Valve Morphogenesis Atrioventricular Valve Morphogenesis Coronary Sinus Valve Morphogenesis Pulmonary Valve Morphogenesis Mitral Valve Formation Endocardial Cushion Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Chamber Formation Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Cardiac Right Atrium Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Formation Ventricular Trabecula Myocardium Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cardioblast Proliferation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Cell Migration Involved In Endocardial Cushion Formation Negative Regulation Of Extracellular Matrix Constituent Secretion Pericardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Import Into Nucleus Apoptotic Process Immune Response Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Spermatogenesis Determination Of Left/right Symmetry Compartment Pattern Specification Axonogenesis Axon Guidance Foregut Morphogenesis Endoderm Development Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Notch Signaling Pathway Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Glial Cell Differentiation Gene Expression Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Myotube Differentiation Mesenchymal Cell Development Regulation Of Somitogenesis Calcium-ion Regulated Exocytosis Cell Differentiation In Spinal Cord Neural Tube Development Central Nervous System Neuron Differentiation Cell Differentiation Protein Catabolic Process Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Lung Development Embryonic Limb Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Forebrain Development Hair Follicle Morphogenesis Animal Organ Regeneration Response To Muramyl Dipeptide Response To Lipopolysaccharide Negative Regulation Of Collagen Biosynthetic Process Embryonic Hindlimb Morphogenesis Tube Formation Skeletal Muscle Cell Differentiation Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Population Proliferation Tissue Regeneration Retinal Cone Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Viral Genome Replication Positive Regulation Of Endothelial Cell Differentiation Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Photoreceptor Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Somatic Stem Cell Division Neuron Fate Commitment Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Venous Blood Vessel Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Glial Cell Proliferation Cilium Assembly Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Cell Adhesion Molecule Production Cardiac Muscle Cell Myoblast Differentiation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Prostate Gland Epithelium Morphogenesis Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Arterial Endothelial Cell Differentiation Venous Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Endocardial Cell Differentiation Vasculogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Neuroendocrine Cell Differentiation Regulation Of Cell Adhesion Involved In Heart Morphogenesis Heart Trabecula Morphogenesis Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Left/right Axis Specification Cellular Response To Tumor Cell Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Hypoxia Distal Tubule Development Collecting Duct Development Regulation Of Stem Cell Proliferation Glomerular Mesangial Cell Development Epithelial Cell Fate Commitment T-helper 17 Type Immune Response Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Interleukin-17-mediated Signaling Pathway Chemical Synaptic Transmission, Postsynaptic Negative Regulation Of Cold-induced Thermogenesis Regulation Of Extracellular Matrix Assembly Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Positive Regulation Of Aorta Morphogenesis Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Anoikis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Endothelial Cell Chemotaxis
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm NFE2L2 regulating tumorigenic genes Regulation of NFE2L2 gene expression Somitogenesis
Drugs
Diseases			Bicuspid aortic valve Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Estimated glomerular filtration rate ( 31152163)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Crohn's disease ( 28067908) Eosinophil count ( 32888494) Inflammatory bowel disease ( 28067908) Length of menstrual cycle ( 26732621) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 28957414) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Ulcerative colitis ( 28067908)
Interacting Genes		59 interacting genes: ASH2L ATN1 CBL CDKN1B CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 ENTREP1 EWSR1 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PTEN PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SLC2A1 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53 TP53BP2 TRAF4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	88 interacting genes: ADAM17 AKT1 APBA1 ARL6IP5 B3GALT4 BLOC1S1 CACNA1A CAMK4 CASR CBL CCN3 CEP57L1 CNTN1 COL4A6 CTNNB1 DAZAP2 DDR1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 EXT1 FAM185A FBP1 FBXW7 FURIN GFI1B GOLGA2 GOPC GSK3B HMGN5 HOXA1 ILK ITCH JAG1 JAG2 KAT2A KAT2B KIAA1191 LCK LEF1 LFNG LINC00260 LINC00261 LINC02907 LNX2 MAGEA1 MAGED1 MAML1 MAML2 MAML3 MAP3K1 MBD1 MDM2 MEF2C MFNG NFKB1 NLK NUMB NUMBL PIK3CG POFUT1 POU2AF1 PRKCD PSEN1 PSEN2 RBP3 RBPJ REL RELA RHOA RUNX3 SHANK3 SMAD3 SNAI1 SNW1 STC1 TLE3 USP10 USP12 USP2 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID		11059	4851
HPRD ID		03811	01827
Ensembl ID		ENSG00000123124	ENSG00000148400
Uniprot IDs		Q9H0M0	P46531
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y 8EI4 9EQK	1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79 4CUD 4CUE 4CUF 4D0E 4D0F 5FM9 5FMA 5KZO 5L0R 5UB5 6IDF 6PY8 8OR5 8ORY 8ORZ 9B3G 9B3N
Enriched GO Terms of Interacting Partners?		WW Domain Binding Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Organ Growth Regulation Of Extracellular Matrix Assembly Regulation Of DNA-templated Transcription Response To Hormone Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Developmental Process Regulation Of Signal Transduction Cell Fate Commitment Positive Regulation Of Biosynthetic Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Modification-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Apoptotic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Developmental Process Apoptotic Process Ubiquitin Ligase Activator Activity Enzyme Binding Regulation Of Protein Metabolic Process	Notch Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Notch Signaling Pathway Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Notch Binding Lymphocyte Activation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Signaling Leukocyte Activation Cell Activation Somitogenesis Regulation Of Cell Development Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Segmentation Positive Regulation Of Cell Differentiation Regulation Of Developmental Process Protein Modification Process Mononuclear Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Tissue Morphogenesis Lymphocyte Differentiation Tube Morphogenesis Regulation Of Gene Expression Positive Regulation Of Developmental Process Leukocyte Differentiation Regulation Of RNA Metabolic Process Regionalization Morphogenesis Of An Epithelium Pattern Specification Process Positive Regulation Of Gene Expression Regulation Of Multicellular Organismal Development Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Biosynthetic Process
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