LATS1 and PPP6R3

Number of citations of the paper that reports this interaction (PMID 22641346)
5

Data Source:
BioGRID (enzymatic study)

		LATS1	PPP6R3
Gene Name		large tumor suppressor kinase 1	protein phosphatase 6, regulatory subunit 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Microtubule Organizing Center Cytosol	Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Binding Protein Phosphatase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX	5 interactors: LATS1 PRKDC TERF2IP TINF2 YWHAG
Entrez ID		9113	55291
HPRD ID		09147	10703
Ensembl ID		ENSG00000131023	ENSG00000110075
Uniprot IDs		O95835	E9PQP7 H7BXH2 Q5H9R7
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process	Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Chromosome Organization Negative Regulation Of Protein Phosphorylation Organelle Organization Negative Regulation Of Phosphorylation Cellular Protein Localization Negative Regulation Of Chromosome Organization Cellular Response To Hormone Stimulus Negative Regulation Of DNA Metabolic Process Protein Localization Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Protein ADP-ribosylation Cellular Localization Response To Hormone Intrinsic Apoptotic Signaling Pathway Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Protein Glycosylation Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity DNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Kinase Activity Pro-B Cell Differentiation Protection From Non-homologous End Joining At Telomere Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Telomere Assembly Response To Insulin Regulation Of Phosphorylation Negative Regulation Of Transferase Activity
Tagcloud ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours
Tagcloud (Difference) ?		accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours
Tagcloud (Intersection) ?