LATS1 and PPP6R3

Number of citations of the paper that reports this interaction (PubMedID 22641346)
57

Data Source:
BioGRID (enzymatic study)

		LATS1	PPP6R3
Description		large tumor suppressor kinase 1	protein phosphatase 6 regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Signal Transduction
Pathways		Signaling by Hippo	Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs		Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Body size at age 10 ( 32376654) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Femoral neck section modulus ( 30888730) Fractures ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monobrow ( 27182965) QT interval ( 29213071) Serum metabolite levels ( 33031748)
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	6 interacting genes: LATS1 PRKDC TERF2IP TINF2 UBC YWHAG
Entrez ID		9113	55291
HPRD ID		09147	10703
Ensembl ID		ENSG00000131023	ENSG00000110075
Uniprot IDs		O95835	E9PKF6 H7BXH2 Q5H9R7
PDB IDs		4ZRK 5B5W 5BRK 7LWH
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	Telomere Capping Negative Regulation Of Phosphorylation Negative Regulation Of Protein Phosphorylation Negative Regulation Of Phosphate Metabolic Process Shelterin Complex Chromosome Organization Regulation Of Protein Phosphorylation Telomere Maintenance Nuclear Telomere Cap Complex Protein Localization To Chromosome Regulation Of Phosphorylation Protein Localization To Chromosome, Telomeric Region Telomere Organization Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Metabolic Process Chromosome, Telomeric Region Protein Localization To Organelle Regulation Of Protein Modification Process Telomeric DNA Binding Intracellular Protein Localization Negative Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Kinase Activity Negative Regulation Of Chromosome Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Cellular Response To Insulin Stimulus Macromolecule Metabolic Process Positive Regulation Of Chromosome Organization Negative Regulation Of Metabolic Process Regulation Of Telomere Maintenance Positive Regulation Of Platelet Formation Perinucleolar Chromocenter Negative Regulation Of DNA Recombination At Telomere Regulation Of Protein Metabolic Process Protein Modification Process DNA-dependent Protein Kinase Activity Small-subunit Processome Assembly Histone H2AXS139 Kinase Activity Protein Kinase C Inhibitor Activity Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Negative Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Translation Pro-B Cell Differentiation Response To Insulin T Cell Receptor V(D)J Recombination
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