LATS1 and STK4

Number of citations of the paper that reports this interaction (PubMedID 15688006)
0

Data Source:
HPRD (in vitro)

		LATS1	STK4
Description		large tumor suppressor kinase 1	serine/threonine kinase 4
Image
GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Midbody Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Nuclear Estrogen Receptor Binding Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Intracellular Protein Localization Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hippo Signaling Positive Regulation Of Hippo Signaling Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Mitotic Cell Cycle Phase Transition Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Density Assembly Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anatomical Structure Morphogenesis Peptidyl-serine Phosphorylation Keratinocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs		Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Bipolar disorder ( 31043756 33263727 34002096) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		52 interacting genes: ALPP APP ARPC3 AURKB CBY2 CDC26 CDK1 CEP76 CREBBP DCAF1 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LOXL2 LRRK2 MAGI3 MAP3K11 MAP3K2 MAP3K3 MAP4K2 MAP4K4 MINK1 MOAP1 MOB3A MOB3B MOB3C MOB4 MTF1 NEDD4 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK4 TAOK1 TFIP11 UBE2I WWOX WWP1 ZYX	25 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 HSPA4 IL2RG KEAP1 LATS1 MBP NEDD4 OGT PICK1 RASSF1 RASSF5 RNF31 RNF6 SAV1 SGMS1 SIRT1 THAP12 TP53 TRIM69
Entrez ID		9113	6789
HPRD ID		09147	05395
Ensembl ID		ENSG00000131023	ENSG00000101109
Uniprot IDs		O95835	A0A087WVN8 Q13043
PDB IDs		4ZRK 5B5W 5BRK 7LWH	2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT 8A5J 8PAV 8PAW
Enriched GO Terms of Interacting Partners?		Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Modification Process Cytoplasm Kinase Activity Protein Kinase Activity Intracellular Signal Transduction Transferase Activity Protein Phosphorylation Phosphorylation MAPK Cascade Intracellular Signaling Cassette Signal Transduction Regulation Of Hippo Signaling Protein Metabolic Process ATP Binding MAP Kinase Kinase Kinase Activity Nucleotide Binding Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Nucleus Regulation Of JNK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Macromolecule Metabolic Process Positive Regulation Of JNK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process JNK Cascade Protein Autophosphorylation Post-translational Protein Modification Protein Binding Regulation Of Cell-matrix Adhesion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Adhesion Regulation Of Cell-substrate Junction Organization Central Nervous System Development Regulation Of Synaptic Vesicle Recycling Cytoskeleton Positive Regulation Of Focal Adhesion Assembly Golgi Disassembly MAP Kinase Kinase Kinase Kinase Activity Tangential Migration From The Subventricular Zone To The Olfactory Bulb Wnt Signaling Pathway, Planar Cell Polarity Pathway Response To Copper Ion	Apoptotic Process Programmed Cell Death Regulation Of Autophagy Cell Death Intracellular Signal Transduction Regulation Of Macroautophagy Response To Stress Regulation Of Proteolysis Identical Protein Binding Regulation Of Protein Metabolic Process Keratinocyte Differentiation Positive Regulation Of Protein Metabolic Process Response To UV Immune System Process Protein Modification Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Hippo Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Regulation Of Glucose Metabolic Process Epidermal Cell Differentiation Glial Cell Apoptotic Process Regulation Of Programmed Necrotic Cell Death PML Body Keratin Filament Binding Signal Transduction Transcription Regulator Inhibitor Activity Positive Regulation Of Metabolic Process Regulation Of Endodeoxyribonuclease Activity Nucleus Regulation Of Post-translational Protein Modification T Cell Differentiation In Thymus Stress-induced Premature Senescence Protein Ubiquitination Post-translational Protein Modification Cytoplasm Regulation Of Hippo Signaling Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Leukocyte Apoptotic Process Cellular Response To Glucose Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Transcription By Glucose Cellular Response To Decreased Oxygen Levels Protein Polyubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Signaling
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