GAS7 and ACTA1

Number of citations of the paper that reports this interaction (PubMedID 11795944)
0

Data Source:
HPRD (in vitro, in vivo)

		GAS7	ACTA1
Description		growth arrest specific 7	actin alpha 1, skeletal muscle
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle	Stress Fiber Extracellular Space Cytoplasm Cytosol Cytoskeleton Striated Muscle Thin Filament Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Hydrolase Activity Myosin Binding ADP Binding
	Biological Process	Nervous System Development Cell Differentiation Clathrin Coat Assembly Neuron Projection Morphogenesis Clathrin-dependent Endocytosis	Muscle Contraction Positive Regulation Of Gene Expression Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Development Mesenchyme Migration
Pathways			Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs			Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases			Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Declining hemoglobin trajectory in blood donors ( 33491795) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 29617998 30054594 29235454 31798171 28073927 31959993 25173106 24002674 22570627) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		28 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MECOM MIR196B MYBPC2 NCKAP1 NCKAP1L NTAQ1 PACSIN1 PKNOX1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A	115 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 LINC00624 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1
Entrez ID		8522	58
HPRD ID		16011	00030
Ensembl ID		ENSG00000007237	ENSG00000143632
Uniprot IDs		O60861	P68133
PDB IDs		2LX7 2YSH	7RNS 7RNU 7RNV 9DUU 9DUV
Enriched GO Terms of Interacting Partners?		SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Lamellipodium Organization Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytosol Cortical Actin Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Lamellipodium Assembly Regulation Of Lamellipodium Assembly MRNA 3'-splice Site Recognition Actin Filament-based Process Regulation Of Actin Filament Polymerization Lamellipodium Morphogenesis Cortical Cytoskeleton Organization Regulation Of Actin Filament Organization Small GTPase Binding Regulation Of Actin Polymerization Or Depolymerization Cell Projection Morphogenesis Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Cell Projection Dendrite Extension Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Myeloid Cell Development Regulation Of Cytoskeleton Organization Hemopoiesis RNA 7-methylguanosine Cap Binding Regulation Of Actin Cytoskeleton Organization Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Cell Morphogenesis Cell Projection Assembly MRNA Splicing, Via Spliceosome MRNA Cis Splicing, Via Spliceosome Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization RNA Splicing, Via Transesterification Reactions Regulation Of Organelle Organization Poly(U) RNA Binding	Actin Binding Actin Filament Binding Cytoskeleton Actin Cytoskeleton Actin Filament-based Process Cytoplasm Actin Filament Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Actin Cytoskeleton Organization Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Length Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytosol Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Cell Cortex Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Cellular Component Organization Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Lamellipodium Ruffle Actin Filament Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Cortical Actin Cytoskeleton Positive Regulation Of Cellular Component Biogenesis Actin Polymerization Or Depolymerization Regulation Of Biological Quality Anchoring Junction Organelle Organization Ruffle Membrane Positive Regulation Of Protein-containing Complex Assembly Cell Projection Filopodium Regulation Of Cell Shape Muscle System Process Negative Regulation Of Actin Filament Depolymerization Regulation Of Protein Localization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?