GAS7 and APBB1IP

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		GAS7	APBB1IP
Gene Name		growth arrest-specific 7	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Actin Filament	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Lamellipodium
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Actin Filament Binding	Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Regulation Of Cell Shape Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament Bundle Assembly	Signal Transduction Blood Coagulation Platelet Activation
Pathways			p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Intraocular pressure ( 22570627)	Inflammatory biomarkers ( 22228203) Response to angiotensin II receptor blocker therapy ( 22566498)
Protein-Protein Interactions		22 interactors: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH HNRNPU KHDRBS1 NCKAP1 NCKAP1L PACSIN1 RPLP0 SF1 SF3A1 SFPQ WAS WASF2 WDYHV1	8 interactors: EVL GAS7 NDN PFN1 PRPF40A RAP1A VASP ZDHHC17
Entrez ID		8522	54518
HPRD ID		16011	16420
Ensembl ID		ENSG00000007237	ENSG00000077420
Uniprot IDs		B7Z1Q2 O60861	B4E100 Q7Z5R6
PDB IDs		2LX7 2YSH	3ZDL
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Lamellipodium Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Nucleation Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Actin Filament Organization MRNA Metabolic Process Lamellipodium Morphogenesis MRNA 3'-splice Site Recognition Positive Regulation Of Immune System Process Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Immune Response Endocytosis Cellular Component Assembly Actin Filament-based Movement Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Organelle Organization MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization Innate Immune Response Regulation Of Cytoskeleton Organization Cellular Response To Stimulus Positive Regulation Of Lamellipodium Assembly Regulation Of Immune Response Megakaryocyte Development Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization RNA Processing Regulation Of Cellular Component Organization Vesicle-mediated Transport Megakaryocyte Differentiation Regulation Of Lamellipodium Assembly Movement Of Cell Or Subcellular Component	Actin Polymerization Or Depolymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Cytoskeleton Organization Regulation Of Ruffle Assembly Nervous System Development Positive Regulation Of Protein Complex Assembly Regulation Of Actin Filament Polymerization Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Actin Filament-based Process Generation Of Neurons Neurogenesis Neuron Projection Development Cell Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Cell Part Morphogenesis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Cellular Component Biogenesis Cell Development Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Neuron Development Regulation Of Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Protein Homotetramerization Cell Morphogenesis Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Differentiation Cell Projection Organization Regulation Of Cell Projection Organization Locomotion Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Protein Tetramerization Neural Tube Closure Axonogenesis System Development Regulation Of Cell Projection Assembly Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neural Tube Formation Response To Growth Factor
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Intersection) ?