GAS7 and PACSIN1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		GAS7	PACSIN1
Gene Name		growth arrest-specific 7	protein kinase C and casein kinase substrate in neurons 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Actin Filament	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Cell Junction COPI-coated Vesicle Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Neuron Projection Axon Terminus Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Actin Filament Binding	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Regulation Of Cell Shape Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament Bundle Assembly	Cytoskeleton Organization Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Synaptic Vesicle Endocytosis Neuron Projection Morphogenesis Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Membrane Tubulation Positive Regulation Of Dendrite Development
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Intraocular pressure ( 22570627)
Protein-Protein Interactions		22 interactors: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH HNRNPU KHDRBS1 NCKAP1 NCKAP1L PACSIN1 RPLP0 SF1 SF3A1 SFPQ WAS WASF2 WDYHV1	24 interactors: ANKRD24 ARHGAP17 ATP8 COBL COBLL1 DNM1 EHBP1 FTH1 GAS7 HTT JADE2 KAT7 KHDRBS1 PACSIN2 PACSIN3 POT1 RTKN2 SOS1 SPTBN1 SYNJ1 TPM4 TRPV4 WASF2 WASL
Entrez ID		8522	29993
HPRD ID		16011	05936
Ensembl ID		ENSG00000007237	ENSG00000124507
Uniprot IDs		B7Z1Q2 O60861	Q5TZC3 Q9BY11
PDB IDs		2LX7 2YSH	3HAH 3HAI 3Q84 3QNI
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Lamellipodium Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Nucleation Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Actin Filament Organization MRNA Metabolic Process Lamellipodium Morphogenesis MRNA 3'-splice Site Recognition Positive Regulation Of Immune System Process Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Immune Response Endocytosis Cellular Component Assembly Actin Filament-based Movement Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Organelle Organization MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization Innate Immune Response Regulation Of Cytoskeleton Organization Cellular Response To Stimulus Positive Regulation Of Lamellipodium Assembly Regulation Of Immune Response Megakaryocyte Development Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization RNA Processing Regulation Of Cellular Component Organization Vesicle-mediated Transport Megakaryocyte Differentiation Regulation Of Lamellipodium Assembly Movement Of Cell Or Subcellular Component	Cell Projection Morphogenesis Cell Part Morphogenesis Actin Filament-based Process Endocytosis Cellular Component Assembly Vesicle-mediated Transport Cell Morphogenesis Regulation Of Cellular Component Organization Organelle Organization Cytoskeleton Organization Cell Projection Organization Actin Cytoskeleton Organization Neuron Development Neuron Projection Morphogenesis Regulation Of Endocytosis Actin Filament-based Movement Endomembrane System Organization Generation Of Neurons Neuron Differentiation Histone H4-K12 Acetylation Membrane Tubulation Neurogenesis Neuron Projection Development Actin Polymerization Or Depolymerization Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Axonogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Protein Polymerization Anatomical Structure Morphogenesis Axon Development Regulation Of Cellular Process Regulation Of Protein Depolymerization Positive Regulation Of Protein Depolymerization Actin Filament Organization Cell Morphogenesis Involved In Neuron Differentiation Membrane Assembly Regulation Of Cell Projection Assembly Regulation Of Protein Complex Disassembly Protein Complex Assembly Movement Of Cell Or Subcellular Component Cellular Protein Complex Assembly Membrane Biogenesis Cell Differentiation Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Complex Disassembly Cell Morphogenesis Involved In Differentiation Axon Guidance
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2	10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2	10a autophagic autophagosome autophagosomes bub1 catabolic cdkl3 csnk1a1 dapk2 endolysosomal flux functioned immortalized kinome macroautophagy maintains manipulation mcf mtorc1 nek4 pklr possibilities protects scyl1 shed sirnas starvation stresses wnk2
Tagcloud (Intersection) ?