GAS7 and NCKAP1L

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		GAS7	NCKAP1L
Gene Name		growth arrest-specific 7	NCK-associated protein 1-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Actin Filament	Cytosol Integral Component Of Plasma Membrane Membrane SCAR Complex Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Actin Filament Binding	Protein Binding Protein Kinase Activator Activity Rac GTPase Activator Activity Protein Complex Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Regulation Of Cell Shape Actin Filament Polymerization Neuron Projection Morphogenesis Actin Filament Bundle Assembly	B Cell Homeostasis Myeloid Cell Homeostasis Protein Complex Assembly Chemotaxis Maintenance Of Cell Polarity Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Positive Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Rac GTPase Activity Positive Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Myosin-light-chain-phosphatase Activity Positive Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Response To Drug T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Protein Kinase Activity Erythrocyte Development B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Actin Polymerization-dependent Cell Motility Positive Regulation Of Neutrophil Chemotaxis
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Intraocular pressure ( 22570627)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		22 interactors: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH HNRNPU KHDRBS1 NCKAP1 NCKAP1L PACSIN1 RPLP0 SF1 SF3A1 SFPQ WAS WASF2 WDYHV1	2 interactors: GAS7 PRPF40A
Entrez ID		8522	3071
HPRD ID		16011	00781
Ensembl ID		ENSG00000007237	ENSG00000123338
Uniprot IDs		B7Z1Q2 O60861	P55160
PDB IDs		2LX7 2YSH
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Lamellipodium Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Nucleation Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Actin Filament Organization MRNA Metabolic Process Lamellipodium Morphogenesis MRNA 3'-splice Site Recognition Positive Regulation Of Immune System Process Lamellipodium Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Immune Response Endocytosis Cellular Component Assembly Actin Filament-based Movement Regulation Of Actin Filament-based Process Positive Regulation Of Cytoskeleton Organization Organelle Organization MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization Innate Immune Response Regulation Of Cytoskeleton Organization Cellular Response To Stimulus Positive Regulation Of Lamellipodium Assembly Regulation Of Immune Response Megakaryocyte Development Regulation Of Immune System Process Positive Regulation Of Lamellipodium Organization RNA Processing Regulation Of Cellular Component Organization Vesicle-mediated Transport Megakaryocyte Differentiation Regulation Of Lamellipodium Assembly Movement Of Cell Or Subcellular Component	Regulation Of Cell Shape Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Cytoskeleton Organization Cell Cycle Actin Filament Polymerization Regulation Of Cytokinesis Actin Filament Bundle Assembly
Tagcloud ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Difference) ?		as1 atoh7 beadchip cav1 cav2 cdkn2b cnvs cyp1b1 duplications fndc3b galc glaugen human660w interrogated kilobases lrp12 merit myoc neighbor optn penncnv poag quad six1 six6 srbd1 tmco1 wdr36 zfpm2
Tagcloud (Intersection) ?