GAS7 and RPLP0

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		GAS7	RPLP0
Description		growth arrest specific 7	ribosomal protein lateral stalk subunit P0
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Clathrin-coated Pit Clathrin-coated Vesicle	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Postsynapse Ribonucleoprotein Complex
	Molecular Function	Protein Binding Identical Protein Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding
	Biological Process	Nervous System Development Cell Differentiation Clathrin Coat Assembly Neuron Projection Morphogenesis Clathrin-dependent Endocytosis	Cytoplasmic Translation Translation Ribosome Biogenesis
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Declining hemoglobin trajectory in blood donors ( 33491795) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Gut microbiota relative abundance (Prevotella) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 29617998 30054594 29235454 31798171 28073927 31959993 25173106 24002674 22570627) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)	Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		28 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CDC37 CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 LSM4 MCRS1 MECOM MIR196B MYBPC2 NCKAP1 NCKAP1L NTAQ1 PACSIN1 PKNOX1 RPLP0 SF1 SF3A1 SFPQ WASF2 YIF1A	15 interacting genes: CSNK2A1 ERG EXOSC8 GAS7 KRI1 LINC00632 OGT PAFAH1B2 PPM1A PRPF40A PTEN SMAD3 STAU1 USP7 YWHAQ
Entrez ID		8522	6175
HPRD ID		16011	01610
Ensembl ID		ENSG00000007237	ENSG00000089157
Uniprot IDs		O60861	P05388
PDB IDs		2LX7 2YSH	4V6W 4V6X 5AJ0 6OLG 6ZM7 6ZME 6ZMI 6ZMO 8G5Z 8G60 8G6J 8K2C 8UKB 8XSX 8XSY 8XSZ 8YOO 8YOP
Enriched GO Terms of Interacting Partners?		SCAR Complex Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Lamellipodium Lamellipodium Organization Positive Regulation Of Actin Nucleation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cytosol Cortical Actin Cytoskeleton Organization Actin Cytoskeleton Organization Positive Regulation Of Lamellipodium Organization Regulation Of Actin Nucleation Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Lamellipodium Assembly Regulation Of Lamellipodium Assembly MRNA 3'-splice Site Recognition Actin Filament-based Process Regulation Of Actin Filament Polymerization Lamellipodium Morphogenesis Cortical Cytoskeleton Organization Regulation Of Actin Filament Organization Small GTPase Binding Regulation Of Actin Polymerization Or Depolymerization Cell Projection Morphogenesis Regulation Of Actin Filament Length Regulation Of Lamellipodium Organization Cell Projection Dendrite Extension Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Myeloid Cell Development Regulation Of Cytoskeleton Organization Hemopoiesis RNA 7-methylguanosine Cap Binding Regulation Of Actin Cytoskeleton Organization Extracellular Exosome Positive Regulation Of Cytoskeleton Organization Cell Morphogenesis Cell Projection Assembly MRNA Splicing, Via Spliceosome MRNA Cis Splicing, Via Spliceosome Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization RNA Splicing, Via Transesterification Reactions Regulation Of Organelle Organization Poly(U) RNA Binding	Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Stabilization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Rhythmic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Negative Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression R-SMAD Binding Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Autophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cellular Localization Regulation Of Gluconeogenesis Cytosol Positive Regulation Of Catabolic Process Membraneless Organelle Assembly Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Regulation Of Cell Junction Assembly Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Focal Adhesion Assembly Negative Regulation Of Wound Healing Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Glucose Stimulus Regulation Of Intracellular Transport Response To Transforming Growth Factor Beta
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