CHLSN and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		CHLSN	FBXO25
Description		cholesin	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding Hormone Activity Protein Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS			Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		6 interacting genes: APP CCDC85B FBXO25 NEDD4L PRNP THAP1	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		84310	26260
HPRD ID		14413	16439
Ensembl ID		ENSG00000146540	ENSG00000147364
Uniprot IDs		Q9BRJ6	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Response To Copper Ion Molecular Function Activator Activity Response To Copper Ion Regulation Of Monoatomic Cation Transmembrane Transport Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Synapse Organization Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Amyloid-beta Positive Regulation Of Calcium-mediated Signaling Regulation Of Metal Ion Transport Response To Amyloid-beta Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Neuron Apoptotic Process Regulation Of Monoatomic Ion Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Type 8 Metabotropic Glutamate Receptor Binding Regulation Of Potassium Ion Transport Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Calcium-mediated Signaling Protein-folding Chaperone Binding Negative Regulation Of RNA Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Type II Interferon Production Lipoprotein Particle Positive Regulation Of Protein Import Memory Regulation Of Plasma Membrane Bounded Cell Projection Organization PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Postsynapse Organization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
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