NSRP1 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
41

Data Source:
BioGRID (enzymatic study)

		NSRP1	FBXO25
Description		nuclear speckle splicing regulatory protein 1	F-box protein 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Processing RNA Splicing Developmental Process	Protein Ubiquitination
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) QRS complex (12-leadsum) ( 27659466)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		11 interacting genes: APP CNR1 CNRIP1 CTNNBL1 DISC1 FBXO25 NEDD4 NEDD4L RANBP9 SRPK1 SRPK2	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 CDK5RAP2 CDK9 CENPB CHLSN CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		84081	26260
HPRD ID		08536	16439
Ensembl ID		ENSG00000126653	ENSG00000147364
Uniprot IDs		A0A024QZ33 B7ZL27 Q9H0G5	Q8TCJ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynapse Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Synapse Organization GABA-ergic Synapse Negative Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Export Across Plasma Membrane Ubiquitin Ligase Complex Cytoplasm Receptor Catabolic Process Positive Regulation Of Protein Metabolic Process Enzyme Binding Negative Regulation Of Potassium Ion Transmembrane Transport Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Neuron Projection Development Negative Regulation Of Potassium Ion Transport Positive Regulation Of Viral Genome Replication Neuromuscular Junction Development Positive Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Glutamatergic Synapse Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Immune Response Regulation Of Amyloid Precursor Protein Catabolic Process Innate Immune Response Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Cell Projection Organization Regulation Of Monoatomic Cation Transmembrane Transport Synapse Organization Receptor Metabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Type 1 Cannabinoid Receptor Binding Protein Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Neuron Cellular Homeostasis Regulation Of Dendrite Morphogenesis Positive Regulation Of Viral Process Regulation Of Potassium Ion Transmembrane Transport	Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Nucleus Polyubiquitin Modification-dependent Protein Binding Cytosol ATP Binding Nucleotide Binding Protein Phosphorylation Phosphorylation Protein Serine/threonine Kinase Activity Apoptotic Process Atrioventricular Node Cell Fate Commitment Nucleoplasm Cell Death Programmed Cell Death Cytoplasm Protein Serine Kinase Activity His-Purkinje System Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Vascular Endothelial Growth Factor Binding Cellular Response To Stress Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Activity Transferase Activity Proteasomal Protein Catabolic Process Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Negative Regulation Of Endothelial Cell Apoptotic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Atrial Septum Development Positive Regulation Of Natural Killer Cell Differentiation Ubiquitin-modified Protein Reader Activity ERAD Pathway Regulation Of Cell Communication Autophagosome Assembly
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