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BARD1 and COL1A1
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
93
Data Source:
BioGRID
(two hybrid)
BARD1
COL1A1
Description
BRCA1 associated RING domain 1
collagen type I alpha 1 chain
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Secretory Granule
Extracellular Matrix
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Tissue Homeostasis
DNA Repair
Regulation Of DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Homologous Recombination
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Protein Export From Nucleus
Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Damage Checkpoint
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Response To Nutrient
Visual Perception
Sensory Perception Of Sound
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Nutrient Levels
Response To Estradiol
Response To Insulin
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of DNA-templated Transcription
Animal Organ Development
Response To Steroid Hormone
Skeletal System Morphogenesis
Embryonic Skeletal System Development
System Development
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Glucose Stimulus
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Response To Fluoride
Cellular Response To Fluoride
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog alfa
Von Willebrand factor human
Diseases
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
21124317
22941191
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Keratoconus (
33649486
)
Response to taxane treatment (docetaxel) (
23006423
)
Interacting Genes
131 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BGLT3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCAF8L2
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AC4
H2BC3
H3C1
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LARP7
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKB1
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RNF10
RPS20
SELENBP1
SETDB1
SKIC8
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
44 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL18A1
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
LAIR1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
TGM2
THBS1
TMPRSS6
TNFAIP3
TXN
UBC
VWF
Entrez ID
580
1277
HPRD ID
03354
00362
Ensembl ID
ENSG00000138376
ENSG00000108821
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
P02452
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
6M14
7E8I
7JZV
7LYB
7LYC
8GRQ
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
7E7B
7E7D
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
Nucleoplasm
DNA Repair
Ubiquitin Conjugating Enzyme Activity
DNA Metabolic Process
Chromosome
Nucleus
Chromatin Organization
Nucleic Acid Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Enzyme Binding
Modification-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Maintenance Of DNA Repeat Elements
Heterochromatin Formation
Negative Regulation Of DNA Recombination
Chromatin Binding
Protein Monoubiquitination
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Single Guanine Insertion Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Ubiquitin-protein Transferase Activity
Negative Regulation Of Gene Expression, Epigenetic
Collagen Binding
Extracellular Matrix
Extracellular Region
Extracellular Matrix Structural Constituent
Extracellular Space
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Extracellular Matrix Binding
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Extracellular Structure Organization
Extracellular Matrix Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Response To Wounding
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Locomotion
Developmental Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Intracellular Signal Transduction
Cell-matrix Adhesion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Endodermal Cell Differentiation
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Cell-substrate Adhesion
Extracellular Exosome
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Signaling
Integrin Binding
Regulation Of Developmental Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Adhesion
Cell Surface
Regulation Of MAPK Cascade
Endoplasmic Reticulum Lumen
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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Tagcloud (Intersection)
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