BARD1 and RPS20

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		BARD1	RPS20
Gene Name		BRCA1 associated RING domain 1	ribosomal protein S20
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm BRCA1-BARD1 Complex Intracellular Membrane-bounded Organelle BRCA1-A Complex	Cytoplasm Cytosol Membrane Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Structural Constituent Of Ribosome Protein Binding Poly(A) RNA Binding
	Biological Process	Tissue Homeostasis DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175)	Height ( 18391951)
Protein-Protein Interactions		107 interactors: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 BRIP1 CAP1 CASC1 CCDC136 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CRIPAK CSTF1 DCC DDX39B EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AFX HAP1 HIST2H2AC HNRNPC HNRNPLL HSPA14 IDI1 IKBKAP ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS3 LGALS8 LRIF1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT2A ND1 NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 XRCC6 ZFP64 ZHX1 ZNF121	14 interactors: APP BARD1 ECT2 IL7R MPHOSPH6 MPP6 NDRG1 NRAS PAXIP1 PIK3CA PLEKHO1 RABAC1 REEP6 SUN2
Entrez ID		580	6224
HPRD ID		03354	04728
Ensembl ID		ENSG00000138376
Uniprot IDs		Q99728	P60866
PDB IDs		1JM7 2NTE 2R1Z 3C5R 3FA2	3J3A
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process Double-strand Break Repair DNA Metabolic Process Gene Expression Chromosome Organization Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Protein Modification By Small Protein Conjugation RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Protein Ubiquitination Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Stress Cell Cycle Checkpoint DNA Recombination Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Meiotic Mismatch Repair Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Modification-dependent Protein Catabolic Process Chromatin Organization DNA Damage Checkpoint Cellular Macromolecule Catabolic Process Immune System Process Viral Process Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated	Positive Regulation Of Protein Metabolic Process Maturation Of 5.8S RRNA Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Cell Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Positive Regulation Of Cell Activation Visual Learning Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Visual Behavior Movement Of Cell Or Subcellular Component Response To Stress Positive Regulation Of Histone H3-K36 Methylation Regulation Of DNA Recombination Anatomical Structure Morphogenesis Regulation Of Immune Response DNA Damage Response, Signal Transduction By P53 Class Mediator Endothelial Cell Migration Positive Regulation Of Protein Modification Process Associative Learning Regulation Of Lymphocyte Activation Regulation Of Cell Cycle Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction In Response To DNA Damage Hypomethylation Of CpG Island Synaptic Growth At Neuromuscular Junction Interleukin-7-mediated Signaling Pathway Negative Regulation Of MRNA 3'-end Processing Blood Coagulation Regulation Of Multicellular Organism Growth Hemostasis Epithelial Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Transport Epithelium Migration Cell Morphogenesis Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Regulation Of Protein Phosphorylation Signal Transduction By P53 Class Mediator
Tagcloud ?		10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	30s 5a 60s amongst atub bestkeeper cyp ef foundation gapdh genorm ginseng housekeeping iia ingredients medicines normalization normfinder optimum panax popular qcr qrt ranked reference rpl13 sar1 stems transcriptomics
Tagcloud (Difference) ?		10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	30s 5a 60s amongst atub bestkeeper cyp ef foundation gapdh genorm ginseng housekeeping iia ingredients medicines normalization normfinder optimum panax popular qcr qrt ranked reference rpl13 sar1 stems transcriptomics
Tagcloud (Intersection) ?