BARD1 and MACROH2A1

Number of citations of the paper that reports this interaction (PubMedID 28564596)
29

Data Source:
BioGRID (enzymatic study)

		BARD1	MACROH2A1
Description		BRCA1 associated RING domain 1	macroH2A.1 histone
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex BRCA1-B Complex BRCA1-C Complex	Nuclear Chromosome Chromosome, Telomeric Region Chromatin Nucleosome Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nucleolus Extracellular Exosome Site Of DNA Damage
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity	RDNA Binding Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Protein Heterodimerization Activity ADP-D-ribose Binding ADP-D-ribose Modification-dependent Protein Binding Poly-ADP-D-ribose Modification-dependent Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Tissue Homeostasis DNA Repair Regulation Of DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Homologous Recombination Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Protein K6-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Oxidative Phosphorylation DNA Repair Chromatin Organization Nucleosome Assembly Dosage Compensation By Inactivation Of X Chromosome Regulation Of Lipid Metabolic Process Heterochromatin Formation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Epigenetic Regulation Of Gene Expression Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling Regulation Of RDNA Heterochromatin Formation Protein Poly-ADP-ribosylation Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of NAD Metabolic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Response To Oxidative Stress Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 21124317 22941191) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)
Interacting Genes		131 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BGLT3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCAF8L2 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AC4 H2BC3 H3C1 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LARP7 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKB1 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RNF10 RPS20 SELENBP1 SETDB1 SKIC8 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655	21 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 CYSRT1 ERICH2 FAM133A H2BC15 KRTAP10-8 NKAPD1 PARP1 RNF168 SPOP SREK1IP1 SRPK1 TRAF2 TRIM26 TRIM59 VCX2 ZNF622
Entrez ID		580	9555
HPRD ID		03354	13624
Ensembl ID		ENSG00000138376	ENSG00000113648
Uniprot IDs		A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728	A0A994J4J7 B4DJC3 O75367
PDB IDs		1JM7 2NTE 2R1Z 3C5R 3FA2 6M14 7E8I 7JZV 7LYB 7LYC 8GRQ	1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC 7D3Y
Enriched GO Terms of Interacting Partners?		DNA Damage Response Nucleoplasm DNA Repair Ubiquitin Conjugating Enzyme Activity DNA Metabolic Process Chromosome Nucleus Chromatin Organization Nucleic Acid Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Protein K48-linked Ubiquitination Double-strand Break Repair Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Enzyme Binding Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Maintenance Of DNA Repeat Elements Heterochromatin Formation Negative Regulation Of DNA Recombination Chromatin Binding Protein Monoubiquitination Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Single Guanine Insertion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression, Epigenetic	Histone H2AK127 Ubiquitin Ligase Activity Protein Polyubiquitination Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Chromatin Organization Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification Process Chromatin Remodeling Ubiquitin Ligase Complex BRCA1-B Complex Protein Modification By Small Protein Conjugation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex Response To Ionizing Radiation Zinc Ion Binding BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Intrinsic Apoptotic Signaling Pathway Innate Immune Response Identical Protein Binding Intracellular Signal Transduction DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of RNA Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair DNA Recombination Protein Metabolic Process Defense Response To Symbiont Defense Response To Other Organism Site Of Double-strand Break Chromatin Binding Ubiquitin-protein Transferase Activity DNA Damage Checkpoint Signaling Response To Other Organism Negative Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Cell Cycle Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA Damage Checkpoint Host-mediated Suppression Of Symbiont Invasion Regulation Of Cellular Response To Stress DNA Repair-dependent Chromatin Remodeling Ubiquitin Protein Ligase Binding Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Programmed Cell Death Protein K6-linked Ubiquitination Regulation Of Phosphorus Metabolic Process
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