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BARD1 and UBE2W
Number of citations of the paper that reports this interaction (PubMedID
37797621
)
66
Data Source:
BioGRID
(pull down, pull down, pull down)
BARD1
UBE2W
Description
BRCA1 associated RING domain 1
ubiquitin conjugating enzyme E2 W
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
Biological Process
Tissue Homeostasis
DNA Repair
Regulation Of DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Homologous Recombination
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Protein Export From Nucleus
Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Damage Checkpoint
Protein Polyubiquitination
DNA Repair
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
DNA Damage Response
Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Cellular Response To Misfolded Protein
Antiviral Innate Immune Response
Negative Regulation Of TORC1 Signaling
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
21124317
22941191
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
Cervical high-risk human papilloma virus infection (
33225922
)
Malaria (
31844061
)
Manganese levels (
26025379
)
Urate levels in obese individuals (
25811787
)
Interacting Genes
131 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BGLT3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCAF8L2
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AC4
H2BC3
H3C1
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LARP7
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKB1
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RNF10
RPS20
SELENBP1
SETDB1
SKIC8
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
81 interacting genes:
AKR1C3
AMFR
ARK2C
ATXN3
BARD1
BFAR
BIRC2
BIRC8
BRCA1
CADPS2
CBL
CHFR
CNOT4
DNMT3B
DTX3
DTX3L
DZIP3
EED
FANCL
LRSAM1
MAP3K1
MAPT
MARCHF3
MARCHF5
MGRN1
MIB1
MID1
MKRN1
MKRN3
MUL1
PJA2
POLR2C
PSTPIP1
RFWD3
RMND5B
RNF10
RNF103
RNF111
RNF114
RNF123
RNF125
RNF138
RNF14
RNF150
RNF152
RNF166
RNF167
RNF183
RNF185
RNF2
RNF26
RNF31
RNF4
RNF5
RNF8
ROPN1
SNCA
STUB1
TOPORS
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM3
TRIM31
TRIM35
TRIM39
TRIM5
TRIM59
TRIM7
TRIM8
UBA1
UBOX5
UFM1
UHRF2
USHBP1
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
580
55284
HPRD ID
03354
07724
Ensembl ID
ENSG00000138376
ENSG00000104343
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
Q96B02
Q96FI0
X6REH9
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
6M14
7E8I
7JZV
7LYB
7LYC
8GRQ
2A7L
2MT6
8A58
Enriched GO Terms of Interacting Partners
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DNA Damage Response
Nucleoplasm
DNA Repair
Ubiquitin Conjugating Enzyme Activity
DNA Metabolic Process
Chromosome
Nucleus
Chromatin Organization
Nucleic Acid Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Enzyme Binding
Modification-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Maintenance Of DNA Repeat Elements
Heterochromatin Formation
Negative Regulation Of DNA Recombination
Chromatin Binding
Protein Monoubiquitination
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Single Guanine Insertion Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Ubiquitin-protein Transferase Activity
Negative Regulation Of Gene Expression, Epigenetic
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Protein Modification Process
Transferase Activity
Zinc Ion Binding
Protein Metabolic Process
Metal Ion Binding
Macromolecule Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Macromolecule Catabolic Process
Protein Autoubiquitination
Proteolysis
Catabolic Process
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Protein Catabolic Process
Response To Stress
Proteasomal Protein Catabolic Process
Cellular Response To Stress
Protein K6-linked Ubiquitination
Ubiquitin Ligase Complex
Regulation Of Intracellular Signal Transduction
Protein Monoubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Signal Transduction
Cytoplasm
Canonical NF-kappaB Signal Transduction
Suppression Of Viral Release By Host
Positive Regulation Of Catabolic Process
Innate Immune Response
Immune System Process
DNA Damage Response
Positive Regulation Of Autophagy
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Response To Other Organism
Regulation Of Autophagy
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Defense Response
Defense Response To Symbiont
Endoplasmic Reticulum Mannose Trimming
Intracellular Signal Transduction
Defense Response To Other Organism
Response To External Biotic Stimulus
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Tagcloud (Intersection)
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