BARD1 and SNX3

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		BARD1	SNX3
Gene Name		BRCA1 associated RING domain 1	sorting nexin 3
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm BRCA1-BARD1 Complex Intracellular Membrane-bounded Organelle BRCA1-A Complex	Cytoplasm Early Endosome Cytosol Endosome Membrane Extrinsic Component Of Membrane Clathrin-coated Vesicle Retromer Complex Early Endosome Membrane Early Phagosome Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Tissue Homeostasis DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Vesicle Organization Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Protein Transport Transferrin Transport Negative Regulation Of Protein Catabolic Process Hemoglobin Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport
Pathways			WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175)
Protein-Protein Interactions		107 interactors: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 BRIP1 CAP1 CASC1 CCDC136 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CRIPAK CSTF1 DCC DDX39B EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AFX HAP1 HIST2H2AC HNRNPC HNRNPLL HSPA14 IDI1 IKBKAP ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS3 LGALS8 LRIF1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT2A ND1 NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 XRCC6 ZFP64 ZHX1 ZNF121	9 interactors: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 SCNN1A STX11 USP10 VPS35
Entrez ID		580	8724
HPRD ID		03354	09333
Ensembl ID		ENSG00000138376	ENSG00000112335
Uniprot IDs		Q99728	O60493
PDB IDs		1JM7 2NTE 2R1Z 3C5R 3FA2	2YPS
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process Double-strand Break Repair DNA Metabolic Process Gene Expression Chromosome Organization Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Protein Modification By Small Protein Conjugation RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Protein Ubiquitination Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Stress Cell Cycle Checkpoint DNA Recombination Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Meiotic Mismatch Repair Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Modification-dependent Protein Catabolic Process Chromatin Organization DNA Damage Checkpoint Cellular Macromolecule Catabolic Process Immune System Process Viral Process Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated	DNA Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Protein K6-linked Ubiquitination Signal Transduction In Response To DNA Damage Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Positive Regulation Of Histone H3-K4 Methylation DNA Metabolic Process Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Histone Methylation DNA Recombination Cellular Response To Stress Regulation Of Histone Acetylation Regulation Of Histone Methylation Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation Response To Stress Response To Radiation Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of Late Endosome To Lysosome Transport Negative Regulation Of Intracellular Transport Regulation Of Histone Modification Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Ubiquitination Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Leukocyte Activation Involved In Immune Response Protein Polyubiquitination Cellular Response To Indole-3-methanol Negative Regulation Of Centriole Replication Lagging Strand Elongation Pro-B Cell Differentiation Negative Regulation Of Protein Export From Nucleus Dosage Compensation By Inactivation Of X Chromosome Neutrophil Degranulation Cytotoxic T Cell Degranulation Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Establishment Of Integrated Proviral Latency Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation
Tagcloud ?		10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles
Tagcloud (Difference) ?		10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	altogether biogenesis degradative depends detachment endocytic endocytosis endosomal endosomes find homology intralumenal knockdown lysosomes maturation multivesicular nexin phosphoinositides prevents px recycling redundant restores retrograde shares snx12 sorting turn vesicles
Tagcloud (Intersection) ?