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BARD1 and MSH6
Number of citations of the paper that reports this interaction (PubMedID
16391231
)
61
Data Source:
BioGRID
(pull down, biochemical)
BARD1
MSH6
Description
BRCA1 associated RING domain 1
mutS homolog 6
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nuclear Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
BRCA1-BARD1 Complex
Cytoplasmic Ribonucleoprotein Granule
BRCA1-A Complex
BRCA1-B Complex
BRCA1-C Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Golgi Apparatus
Cytosol
MutSalpha Complex
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Kinase Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Heterodimerization Activity
Ubiquitin Protein Ligase Activity
Ubiquitin-modified Histone Reader Activity
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
Histone H3K36me3 Reader Activity
ATP-dependent DNA Damage Sensor Activity
Biological Process
Tissue Homeostasis
DNA Repair
Regulation Of DNA Repair
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Homologous Recombination
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Protein Export From Nucleus
Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Protein K6-linked Ubiquitination
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Damage Checkpoint
Meiotic Mismatch Repair
DNA Repair
Mismatch Repair
Chromatin Organization
DNA Damage Response
Spermatogenesis
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Intrinsic Apoptotic Signaling Pathway
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
UCH proteinases
Metalloprotease DUBs
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective DNA double strand break response due to BRCA1 loss of function
Defective DNA double strand break response due to BARD1 loss of function
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
Drugs
Diseases
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
GWAS
Feeling fed-up (
29500382
)
General risk tolerance (MTAG) (
30643258
)
Neuroblastoma (
21124317
22941191
)
Neuroblastoma (high-risk) (
19412175
)
Neuroblastoma (MYCN amplification) (
28924153
)
Neurociticism (
29500382
)
Sporadic neuroblastoma (
28545128
)
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Lifetime average cigarettes per day in chronic obstructive pulmonary disease (
21685187
)
Menopause (age at onset) (
26414677
)
Takayasu arteritis (
25604533
)
Tea consumption (
31046077
)
Interacting Genes
131 interacting genes:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
AXIN2
BCCIP
BCL3
BGLT3
BRCA1
BRD7
CAP1
CBX1
CBX3
CBX5
CCDC136
CDK1
CDK2
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CSTF1
DCAF8L2
DCC
DDX39B
DNAI7
ELP1
ESR1
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AC20
H2AC4
H2BC3
H3C1
HAP1
HNRNPC
HNRNPLL
HSF2BP
HSPA14
IDI1
IKZF1
ING5
KAT5
KAT7
KBTBD7
KIFC3
KRT40
LARP7
LDOC1
LGALS8
LRIF1
MACROH2A1
MAGED1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT-ND1
MT2A
MTUS2
NFKB1
NFKBIA
NPC2
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
PIN1
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RABEP1
RAD51
RBBP8
RBMY2BP
RNF10
RPS20
SELENBP1
SETDB1
SKIC8
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TERF2
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WRN
XRCC6
ZFP64
ZHX1
ZNF121
ZNF655
20 interacting genes:
BARD1
BRCA1
CEBPA
CHAF1A
CREBBP
CSNK2A1
EP300
HRAS
HUS1
MAP2K1
MSH2
MUTYH
NANS
PCNA
PTEN
RAD1
RAD9A
SMC1A
SUMO2
WEE2-AS1
Entrez ID
580
2956
HPRD ID
03354
07202
Ensembl ID
ENSG00000138376
ENSG00000116062
Uniprot IDs
A0A087WZ19
A0AVN2
C9IYG1
F6MDI0
F6MDI1
F6MDI2
Q99728
A0A494C0M1
A0A8V8TPJ4
P52701
Q3SWU9
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
6M14
7E8I
7JZV
7LYB
7LYC
8GRQ
2GFU
2O8B
2O8C
2O8D
2O8E
2O8F
6OQM
8AG6
Enriched GO Terms of Interacting Partners
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DNA Damage Response
Nucleoplasm
DNA Repair
Ubiquitin Conjugating Enzyme Activity
DNA Metabolic Process
Chromosome
Nucleus
Chromatin Organization
Nucleic Acid Metabolic Process
Chromosome, Telomeric Region
Regulation Of DNA Metabolic Process
Chromatin Remodeling
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Epigenetic Regulation Of Gene Expression
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Double-strand Break Repair
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Chromosome Organization
Enzyme Binding
Modification-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA Metabolic Process
Ubiquitin Protein Ligase Binding
Post-translational Protein Modification
Maintenance Of DNA Repeat Elements
Heterochromatin Formation
Negative Regulation Of DNA Recombination
Chromatin Binding
Protein Monoubiquitination
Regulation Of Gene Expression
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Single Guanine Insertion Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Ubiquitin-protein Transferase Activity
Negative Regulation Of Gene Expression, Epigenetic
Cellular Response To Radiation
DNA Repair
DNA Damage Response
Response To Radiation
DNA Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Damaged DNA Binding
Response To Ionizing Radiation
Cellular Response To Ionizing Radiation
Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Response To Stress
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle
Checkpoint Clamp Complex
Nucleobase-containing Compound Metabolic Process
Signal Transduction In Response To DNA Damage
Intracellular Signal Transduction
Regulation Of Cell Cycle Phase Transition
MutLalpha Complex Binding
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of Cellular Response To Stress
Negative Regulation Of Mitotic Cell Cycle
Nucleus
DNA Recombination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Intra-S DNA Damage Checkpoint Signaling
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Regulation Of Transcription By RNA Polymerase II
BRCA1-BARD1 Complex
Chromatin Binding
Response To UV
Histone H3K27 Acetyltransferase Activity
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Catabolic Process
Histone H3K18 Acetyltransferase Activity
N-terminal Peptidyl-lysine Acetylation
Peptide Lactyltransferase (CoA-dependent) Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
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