ARF6 and AP3B1

Number of citations of the paper that reports this interaction (PMID 11926829)
12

Data Source:
HPRD (in vitro)

		ARF6	AP3B1
Gene Name		ADP-ribosylation factor 6	adaptor-related protein complex 3, beta 1 subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Endosome Early Endosome Golgi Apparatus Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Midbody Filopodium Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Vesicular Exosome	Lysosomal Membrane Golgi Apparatus Membrane AP-3 Adaptor Complex Clathrin-coated Vesicle Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Thioesterase Binding	Protein Phosphatase Binding GTP-dependent Protein Binding
	Biological Process	Liver Development Movement Of Cell Or Subcellular Component Cell Cycle Cell Adhesion Small GTPase Mediated Signal Transduction Metabolic Process Protein Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Ruffle Organization Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Cell Division Regulation Of Filopodium Assembly Regulation Of Dendritic Spine Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Hepatocyte Apoptotic Process	Protein Targeting To Lysosome Intracellular Protein Transport Blood Coagulation Anterograde Axon Cargo Transport Melanosome Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Anterograde Synaptic Vesicle Transport Positive Regulation Of NK T Cell Differentiation
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Insulin resistance/response ( 21901158)
Protein-Protein Interactions		28 interactors: AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARRB1 ARRB2 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR GGA1 IKBKG ITSN1 MPP5 PIP5K1A PIP5K1C PLD1 RAB11FIP3 RAB11FIP4 RAB11FIP5 ZNF709	10 interactors: AP3S2 ARF1 ARF5 ARF6 ARR3 BUB1 BUB1B CLTC CSNK1A1 SLC30A3
Entrez ID		382	8546
HPRD ID		02714	04551
Ensembl ID			ENSG00000132842
Uniprot IDs		P62330	E5RJ68 O00203
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cellular Localization Protein Localization Establishment Of Localization In Cell Establishment Of Protein Localization Transport Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Transport Protein Transport Movement Of Cell Or Subcellular Component Axon Cargo Transport Endocytosis Establishment Of Organelle Localization Receptor Metabolic Process Regulation Of GTPase Activity Anterograde Synaptic Vesicle Transport Regulation Of ARF Protein Signal Transduction Intracellular Transport Chemotaxis Anterograde Axon Cargo Transport Regulation Of Ras Protein Signal Transduction Organelle Localization Cellular Protein Localization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Transport Receptor Internalization Cytoskeleton-dependent Intracellular Transport Response To External Stimulus Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Synaptic Transmission Actin Cytoskeleton Organization Locomotion Cell-cell Signaling Platelet Activation Cytoskeletal Anchoring At Plasma Membrane Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction G-protein Coupled Receptor Internalization Blood Coagulation Hemostasis Regulation Of Signal Transduction Post-Golgi Vesicle-mediated Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway	Vesicle-mediated Transport Mitotic Nuclear Division Cell Division Protein Localization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Transport Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Chromosome Segregation Protein Transport Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Establishment Of Protein Localization Mitotic Cell Cycle Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Organelle Organization Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Protein Localization Cellular Localization Small GTPase Mediated Signal Transduction Mitotic Cell Cycle Checkpoint Endocytosis Regulation Of Sequestering Of Zinc Ion Regulation Of Endocytosis Regulation Of Proteasomal Protein Catabolic Process Establishment Of Vesicle Localization Myeloid Cell Apoptotic Process Regulation Of Chromosome Organization Vesicle Localization
Tagcloud ?		accessible cellubrevin cho colocalized compartment cryoimmunogold endocytic endosomal gdp gtpase horseradish hrp invaginations localize localizes morphologically pericentriolar perinuclear perturbs q67l recycling resembled ribosylation shortly t27n tracer uniquely vesicles	amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca
Tagcloud (Difference) ?		accessible cellubrevin cho colocalized compartment cryoimmunogold endocytic endosomal gdp gtpase horseradish hrp invaginations localize localizes morphologically pericentriolar perinuclear perturbs q67l recycling resembled ribosylation shortly t27n tracer uniquely vesicles	amd3100 bl bortezomib c57bl6 canine cathepsin cbcs cfu cfus ch counts cyclic cyclophosphamide dilution elastase gemm granulocyte granulopoiesis hermansky hps lin lsk mobilization myeloperoxidase neutropenia neutropenic pearl pudlak sca
Tagcloud (Intersection) ?