ARF6 and ALDH5A1

		ARF6	ALDH5A1
Description		ARF GTPase 6	aldehyde dehydrogenase 5 family member A1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Mitochondrion Mitochondrial Matrix Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Succinate Metabolic Process Glutamate Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Carboxylic Acid Metabolic Process Synaptic Transmission, GABAergic
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Degradation of GABA
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	Succinic acid NADH Valproic acid Chlormerodrin
Diseases			Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	4 interacting genes: ABAT CLIC6 MAGEA11 OGT
Entrez ID		382	7915
HPRD ID		02714	08361
Ensembl ID		ENSG00000165527	ENSG00000112294
Uniprot IDs		P62330	P51649 X5D299 X5DQN2
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	(S)-3-amino-2-methylpropionate Transaminase Activity Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate Transaminase Complex 4-aminobutyrate:2-oxoglutarate Transaminase Activity Regulation Of Rac Protein Signal Transduction Erythrocyte Apoptotic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly D4 Dopamine Receptor Binding Positive Regulation Of Prolactin Secretion Gamma-aminobutyric Acid Catabolic Process Positive Regulation Of Aspartate Secretion Copulation Negative Regulation Of Gamma-aminobutyric Acid Secretion D3 Dopamine Receptor Binding Positive Regulation Of Protein Secretion Regulation Of Protein Localization To Cell Periphery Regulation Of Synapse Assembly Protein Localization To Cleavage Furrow Protein O-acetylglucosaminyltransferase Activity D2 Dopamine Receptor Binding Positive Regulation Of Dopamine Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Modulation Of Inhibitory Postsynaptic Potential Negative Regulation Of Dopamine Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Localization Positive Regulation Of Protein Transport Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Regulation Of Protein Localization To Membrane Maintenance Of Postsynaptic Density Structure Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Secretion Gamma-aminobutyric Acid Metabolic Process Regulation Of Cell Junction Assembly Positive Regulation Of Focal Adhesion Disassembly Regulation Of Uterine Smooth Muscle Contraction Regulation Of Transcription By Glucose Positive Regulation Of Heat Generation Positive Regulation Of Secretion By Cell Thioesterase Binding Positive Regulation Of Keratinocyte Migration Maintenance Of Postsynaptic Specialization Structure
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