ARF6 and CYTH1

Number of citations of the paper that reports this interaction (PubMedID 17846866)
0

Data Source:
BioGRID (pull down)

		ARF6	CYTH1
Description		ARF GTPase 6	cytohesin 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Membrane Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Vesicle-mediated Transport Regulation Of Cell Adhesion Regulation Of ARF Protein Signal Transduction Establishment Of Epithelial Cell Polarity
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Intra-Golgi traffic
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271) Ferritin levels ( 33491795)	Anxiety and major depressive disorder ( 24047446) Atrial fibrillation ( 30061737) HDL cholesterol levels ( 32203549) Pulse pressure ( 27841878 30578418) Red cell distribution width ( 32888494) Systolic blood pressure ( 27841878)
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	13 interacting genes: ACTA1 ARF1 ARF6 ARFRP1 CYTIP FOSL2 GNAQ ITGB2 ITSN1 PCNT PRKCD SNAPC5 TRIM23
Entrez ID		382	9267
HPRD ID		02714	01630
Ensembl ID		ENSG00000165527	ENSG00000108669
Uniprot IDs		P62330	B7Z9W0 K7ENQ8 Q15438
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	1BC9 4A4P
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	GTPase Activity GTP Binding Endomembrane System Nucleotide Binding Vesicle-mediated Transport Positive Regulation Of Establishment Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Metabolic Process Sarcomere Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Transport Membrane Invagination Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Presynaptic Endocytosis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Regulation Of Cellular Localization Regulation Of Filopodium Assembly Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Erythrocyte Apoptotic Process Positive Regulation Of Protein Transport Fat Cell Apoptotic Process B Cell Proliferation Regulation Of Platelet Activation Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Endosomal Transport Regulation Of Actin Filament Organization Intracellular Protein Localization Intracellular Transport GDP Binding Enzyme Activator Activity Regulation Of Biological Quality Cleavage Furrow Ingression Regulation Of Endocytosis Positive Regulation Of Secretion By Cell Protein Localization To Membrane G Protein Activity Lung Connective Tissue Development Alveolar Secondary Septum Development Regulation Of Body Fluid Levels Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Positive Regulation Of Reactive Oxygen Species Metabolic Process Integrin AlphaL-beta2 Complex
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